Purpose: Epidermal growth factor receptor (EGFr) is overexpressed in a majority of head
and neck squamous cell carcinomas, and this overexpression is associated with a poor …

Background Monoclonal antibodies (mAb) to epidermal growth factor receptor (EGFr) inhibit
tumor cell proliferation and enhance cytotoxicity of chemotherapeutic agents. The purpose …

Purpose : To investigate treatment of human pancreatic cancer cell lines and xenografts with
combinations of Erbitux (IMC-C225) anti-epidermal growth factor receptor (EGFR) antibody, …

Cholangiocarcinoma is a virtually incurable tumor, resistant to current surgical, chemotherapy,
and radiotherapy interventions. We applied the gene therapy strategy of toxin gene …

Overexpression of proapoptotic Bax favors death in cells resistant to ionizing radiation. We
hypothesized that expression of Bax via adenoviral-mediated gene delivery could sensitize …

MATERIALS AND METHODS All chemicals were purchased from Aldrich (Milwaukee, WI)
unless noted otherwise. Na'25I and [125I]-Tyr4-bombesin [specific activities of each  «Â «…

Apoptosis induction is a promising approach for cancer gene therapy. Bax is a death-promoting
member of the Bcl2 family of genes that are intimately involved in apoptosis. …

PURPOSE:: We explore the utility of the adenovirus-mediated delivery of proapoptotic Bax
for enhancing the cytotoxicity of radiotherapy (RT) in RT-refractory glioma cells. METHODS …

Peptide-displayed phage libraries are billion-clone collections of diverse chimeric bacteriophage
particles, decorated by genetically fused peptides built from a random combination of …

Radioimmunotherapy is limited by a variety of factors, including poor tumor penetration of
monoclonal antibodies and low levels of intratumoral antigen expression. To address these …