NMR solution structures of stereoisomeric covalent polycyclic aromatic carcinogen− DNA adducts: principles, patterns, and diversity
NE Geacintov, M Cosman, BE Hingerty… - Chemical research in …, 1997 - ACS Publications
Exogenous chemicals have been implicated in causing mutations that are responsible for
the initiation and progression of tumors (1r5). Mutations in the p53 gene, a tumor suppressor …
the initiation and progression of tumors (1r5). Mutations in the p53 gene, a tumor suppressor …
Solution conformation of the major adduct between the carcinogen (+)-anti-benzo [a] pyrene diol epoxide and DNA.
M Cosman, C De Los Santos, R Fiala… - Proceedings of the …, 1992 - National Acad Sciences
We have synthesized, separated, and purified approximately 10 mg of a deoxyundecanucleotide
duplex containing a single centrally positioned covalent adduct between (+)-anti-benzo[…
duplex containing a single centrally positioned covalent adduct between (+)-anti-benzo[…
Inorganic and organic sulfur cycling in salt-marsh pore waters
GW Luther III, TM Church, JR Scudlark, M Cosman - Science, 1986 - science.org
Sulfur species in pore waters of the Great Marsh, Delaware, were analyzed seasonally by
polarographic methods. The species determined (and their concentrations in micromoles per …
polarographic methods. The species determined (and their concentrations in micromoles per …
Solution conformation of the (+)-cis-anti-[BP] dG adduct in a DNA duplex: intercalation of the covalently attached benzo [a] pyrenyl ring into the helix and displacement …
M Cosman, C De Los Santos, R Fiala, BE Hingerty… - Biochemistry, 1993 - ACS Publications
This paper reports on the solution structure of the (+)-c¡ j-anf/-[BP] dG adduct positioned
opposite dC in a DNA oligomer duplex which provides the first experimentally based solution …
opposite dC in a DNA oligomer duplex which provides the first experimentally based solution …
Influence of benzo [a] pyrenediol epoxide chirality on solution conformations of DNA covalent adducts: the (-)-trans-anti-[BP] G. cntdot. C adduct structure and …
C De Los Santos, M Cosman, BE Hingerty… - Biochemistry, 1992 - ACS Publications
Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons,
Columbia University, New York, New York 10032, Health and Safety Research Division, …
Columbia University, New York, New York 10032, Health and Safety Research Division, …
Monitoring dynamic protein expression in living E. coli. Bacterial cells by laser tweezers Raman spectroscopy
…, MH Corzett, JM Ulloa, M Cosman… - Cytometry Part A: the …, 2007 - Wiley Online Library
Background: Laser tweezers Raman spectroscopy (LTRS) is a novel, nondestructive, and
label‐free method that can be used to quantitatively measure changes in cellular activity in …
label‐free method that can be used to quantitatively measure changes in cellular activity in …
Solution Conformation of the (−)-cis-anti-Benzo[a]pyrenyl-dG Adduct Opposite dC in a DNA Duplex: Intercalation of the Covalently Attached BP Ring into the Helix …
M Cosman, BE Hingerty, N Luneva, S Amin… - Biochemistry, 1996 - ACS Publications
This paper reports on the combined NMR−molecular mechanics computational studies of the
solution structure of the (−)-cis-anti-[BP]dG adduct positioned opposite dC in the sequence …
solution structure of the (−)-cis-anti-[BP]dG adduct positioned opposite dC in the sequence …
Solution structure of the 2-amino-1- methyl-6-phenylimidazo[4,5-b]pyridine C8-deoxyguanosine adduct in duplex DNA
…, S Broyde, KW Turteltaub, M Cosman - Proceedings of the …, 2001 - National Acad Sciences
The carcinogenic heterocyclic amine (HA) 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
(PhIP) is formed during the cooking of various meats. To enable structure/activity studies …
(PhIP) is formed during the cooking of various meats. To enable structure/activity studies …
Solution conformation of the (+)-trans-anti-[BP] dG adduct opposite a deletion site in a DNA duplex: intercalation of the covalently attached benzo [a] pyrene into the …
M Cosman, R Fiala, BE Hingerty, S Amin… - Biochemistry, 1994 - ACS Publications
Revised Manuscript Received July 28, 1994Ū abstract: This paper reports on the solution
structure of the (+)-Zrani-a/zZz-[BP] dG adduct positioned opposite a deletion site in a DNA …
structure of the (+)-Zrani-a/zZz-[BP] dG adduct positioned opposite a deletion site in a DNA …
Preparation and isolation of adducts in high yield derived from the binding of two benzo[a]pyrene-7,8-dihydroxy-9,10-oxide stereoisomers to the oligonucleotide d …
M Cosman, V Ibanez, NE Geacintov… - …, 1990 - academic.oup.com
The reaction of the (+)- and (−)-enantlomers of BDPE (trans-7,8-dihydroxy-anti-9,1O-epoxy-7,8,9,10-tetrahydrobenzo-[a]pyrene)
with the oligodeoxynucleotide d(ATATGTATA) in …
with the oligodeoxynucleotide d(ATATGTATA) in …