Exploratory eye movement dysfunction as a discriminator for schizophrenia: a large sample study using a newly developed digital computerized system

…, R Kawahara, T Otsuka, Y Hirayasu, M Sekine… - European archives of …, 2009 - Springer
In our previous studies, we identified that exploratory eye movement (EEM) dysfunction
appears to be specific to schizophrenia. The availability of a biological marker specific to …

Occupancy of serotonin and norepinephrine transporter by milnacipran in patients with major depressive disorder: a positron emission tomography study with [11C] …

…, T Mori, H Shimada, H Fukuda, M Sekine… - International Journal …, 2013 - academic.oup.com
Antidepressants used for treatment of depression exert their efficacy by blocking reuptake at
serotonin transporters (5-HTT) and/or norepinephrine transporters (NET). Recent studies …

Norepinephrine transporter occupancy by antidepressant in human brain using positron emission tomography with (S,S)-[18F]FMeNER-D2

M Sekine, R Arakawa, H Ito, M Okumura, T Sasaki… - …, 2010 - Springer
Rationale Central norepinephrine transporter (NET) is one of the main targets of antidepressants.
Although the measurement of NET occupancy has been attempted in humans, the …

Quantitative analysis of peripheral benzodiazepine receptor in the human brain using PET with 11C-AC-5216

…, T Otsuka, F Kodaka, M Sekine… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Peripheral benzodiazepine receptor (PBR) is upregulated in activated glial cells and is
therefore a useful biomarker for inflammation in the brain and neurodegenerative disorders. We …

Quantitative PET analysis of the dopamine D2 receptor agonist radioligand 11C-(R)-2-CH3O-Nn-propylnorapomorphine in the human brain

…, F Kodaka, M Miyoshi, M Sekine… - Journal of Nuclear …, 2009 - Soc Nuclear Med
It has been demonstrated in vitro that the dopamine D 2 receptor has 2 interconvertible affinity
states for endogenous dopamine, referred to as the high- and the low-affinity states. C-(R)-…

Relationships between exploratory eye movement dysfunction and clinical symptoms in schizophrenia

…, T Otsuka, Y Hirayasu, M Sekine… - Psychiatry and …, 2012 - Wiley Online Library
Aim: Many psychophysiological tests have been widely researched in the search for a
biological marker of schizophrenia. The exploratory eye movement (EEM) test involves the …

[HTML][HTML] Eating disorders among patients incarcerated only for repeated shoplifting: a retrospective quasi-case-control study in a medical prison in Japan

T Asami, Y Okubo, M Sekine, T Nomura - BMC psychiatry, 2014 - Springer
Background Shoplifting is a serious problem among patients with eating disorders. For
more than a decade, we have treated many patients with eating disorders incarcerated in …

[HTML][HTML] Central nervous system drug evaluation using positron emission tomography

M Sekine, J Maeda, H Shimada, T Nogami… - Clinical …, 2011 - ncbi.nlm.nih.gov
In conventional pharmacological research in the field of mental disorders, pharmacological
effect and dose have been estimated by ethological approach and in vitro data of affinity to …

[HTML][HTML] Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients

…, M Nakajima, Y Sekine… - The Journal of …, 2007 - Am Soc Clin Investig
Autism, characterized by profound impairment in social interactions and communicative
skills, is the most common neurodevelopmental disorder, and its underlying molecular …

[HTML][HTML] Identification of a new serine kinase that activates NF kappa B by direct phosphorylation.

T Hayashi, T Sekine, T Okamoto - Journal of Biological Chemistry, 1993 - Elsevier
A novel serine kinase, named nuclear factor kappa B (NF kappa B) kinase, has been shown
to be associated with the NF kappa BI kappa B complex in the cytosol of human primary T …