The human microbiome is an integral component of the human body and a co-determinant of
several health conditions 1 , 2 . However, the extent to which interpersonal relations shape …

The mechanisms that sustain endometrial tissues at ectopic sites in patients with
endometriosis are poorly understood. Various leukocytes, including macrophages, infiltrate …

The poor selective toxicity of chemotherapeutic anticancer drugs leads to dose-limiting side
effects that compromise clinical outcome. Solid tumors recruit new blood vessels to support …

Neuroblastoma, the most common solid tumor of infancy derived from the sympathetic
nervous system, continues to present a formidable clinical challenge. Sterically stabilized …

Neuroblastoma (NB) is a pediatric tumor that originates from neural crest-derived cells
undergoing a defective differentiation due to genomic and epigenetic impairments. Therefore, NB …

Purpose: Fenretinide (4HPR), a synthetic retinoid, induces apoptosis in neuroblastoma cells.
A Phase I study in children with neuroblastoma was designed to determine maximum …

Neuroblastoma (NB) is the most common extracranial solid tumor in children. Intensive
therapeutic intervention does not prolong the overall disease-free survival rate for this tumor. NB …

Background Malignant melanoma is one of the most aggressive skin cancer and chemotherapeutic
agents currently in use are still unsatisfactory. Prevention and early diagnosis are the …

Retinoids exert various important biological effects in the control of normal growth,
differentiation, and fetal development. While retinoic acid (RA) has entered clinical trials as a …

Macrophages, cells belonging to the innate immune system, present a high plasticity grade,
being able to change their phenotype in response to environmental stimuli. They play …