Persistence of T cells engineered with chimeric antigen receptors (CARs) has been a major
barrier to use of these cells for molecularly targeted adoptive immunotherapy. To address …

Malignant gliomas are the most common primary brain tumors in adults, have no known
etiology, and are generally rapidly fatal despite current therapies. Human cytomegalovirus (…

Background Colorectal cancer is the second most frequent cause of death from cancer in
the USA, and most tumours arise sporadically with no clear cause or genetic predisposition. …

Purpose : Recent epidemiological data indicate that a history of increased exposure to
sexually transmitted diseases is associated with an increased risk of prostate cancer. Human …

Although BRAF and MEK inhibitors have proven clinical benefits in melanoma, most
patients develop resistance. We report a de novo MEK2-Q60P mutation and BRAF gain in a …

Malignant gliomas are the most common primary brain tumors in adults, and the most
malignant form, glioblastoma multiforme (GBM), is usually rapidly fatal. Most GBMs do not have …

Glycoprotein B (gB), along with gD, gH, and gL, is essential for herpes simplex virus (HSV)
entry. The crystal structure of the gB ectodomain revealed it to be an elongated multidomain …

The Cub and Sushi Multiple Domains-1 (CSMD1) is a tumor suppressor gene on 8p23.2,
where allelic loss is both frequent and associated with poor prognosis in head and neck …

Based on previous findings of increased nitric oxide synthase (NOS) expression in human
gliomas (4), we hypothesized that peroxynitrite, a highly reactive metabolite of nitric oxide (NO…

Background High-risk neuroblastoma is a complex genetic disease that is lethal in more
than 50% of patients despite intense multimodal therapy. Through genome-wide association …