Fluorinated 2-arylbenzothiazoles are new potential antitumor drugs, which show potent and
selective inhibitory activity against breast, lung, and colon cancer cell lines. Carbon-11 …

The purinergic receptor subtype 7 (P2X7R) represents a novel molecular target for imaging
neuroinflammation via PET. GSK1482160, a potent P2X7R antagonist, has high receptor …

Iressa (Gefitinib) is an orally active inhibitor of epidermal growth factor receptor tyrosine kinase
(EGFR-TK) involved in cell signal transduction processes critical to proliferation, apoptosis…

The authentic standards GSK1482160 and its isomer, as well as the radiolabeling precursors
desmethyl-GSK1482160 and Boc-protected desmethyl-GSK1482160 were synthesized …

The translocator protein 18kDa (TSPO) is an attractive target for molecular imaging of
neuroinflammation and tumor progression. [ 18 F]PBR06, a fluorine-18 labeled form of PBR06, is a …

New carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
derivatives were designed and synthesized as potential positron emission …

GSK2126458 is a highly potent inhibitor of phosphoinositide 3-kinase (PI3K) and
mammalian target of rapamycin (mTOR) with low picomolar to subnanomolar activity. [ 11 C]…

[ 11 C]DAA1106 was prepared by O-[ 11 C]methylation of DAA1123 with [ 11 C]CH 3 OTf
and NaH in CH 3 CN at 80C and isolated by HPLC combined with SPE purification in 60–70% …

Improved syntheses of dopamine D 2 /D 3 receptor radioligands [ 11 C]Fallypride and [ 18 F]Fallypride
are reported. The phenolic precursor (9) for C-11 labeling and the Fallypride (10) …

Fully automated synthesis and initial PET evaluation of a TSPO radioligand, [ 11 C]PBR28 (N-(2-[
11 C]methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamide), are reported. These …