Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance
…, SW Minaker, HF Zhang, M Colovic… - Proceedings of the …, 2019 - National Acad Sciences
The RAS family of proto-oncogenes are among the most commonly mutated genes in human
cancers and predict poor clinical outcome. Several mechanisms underlying oncogenic …
cancers and predict poor clinical outcome. Several mechanisms underlying oncogenic …
18F-Fluorination of Unactivated C–H Bonds in Branched Aliphatic Amino Acids: Direct Synthesis of Oncological Positron Emission Tomography Imaging Agents
MB Nodwell, H Yang, M Čolović, Z Yuan… - Journal of the …, 2017 - ACS Publications
A mild and selective photocatalytic C–H 18 F-fluorination reaction has been developed that
provides direct access to 18 F-fluorinated amino acids. The biodistribution and uptake of …
provides direct access to 18 F-fluorinated amino acids. The biodistribution and uptake of …
Liquid chromatographic determination of minocycline in brain-to-plasma distribution studies in the rat
M Colovic, S Caccia - Journal of Chromatography B, 2003 - Elsevier
An isocratic reversed-phase high-performance liquid chromatographic procedure was
developed for the determination of minocycline in rat plasma and brain and applied to brain-to-…
developed for the determination of minocycline in rat plasma and brain and applied to brain-to-…
Glutamate AMPA receptors change in motor neurons of SOD1G93A transgenic mice and their inhibition by a noncompetitive antagonist ameliorates the progression …
…, E Zennaro, G Spaltro, M Colovic… - Journal of …, 2006 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder involving the selective
degeneration of motor neurons. In a small proportion of patients, ALS is caused by mutations in …
degeneration of motor neurons. In a small proportion of patients, ALS is caused by mutations in …
18F-5-Fluoroaminosuberic acid as a potential tracer to gauge oxidative stress in breast cancer models
H Yang, S Jenni, M Colovic, H Merkens… - Journal of Nuclear …, 2017 - Soc Nuclear Med
The cystine transporter (system x C − ) is an antiporter of cystine and glutamate. It has relatively
low basal expression in most tissues and becomes upregulated in cells under oxidative …
low basal expression in most tissues and becomes upregulated in cells under oxidative …
Electrostatic Effects Accelerate Decatungstate-Catalyzed C–H Fluorination Using [18F]- and [19F]NFSI in Small Molecules and Peptide Mimics
Z Yuan, H Yang, N Malik, M Colovic, DS Weber… - ACS …, 2019 - ACS Publications
The site-selective fluorination of unactivated C(sp 3 )-H bonds provides unique opportunities
to rapidly alter drug properties or generate radiotracers for positron emission tomography (…
to rapidly alter drug properties or generate radiotracers for positron emission tomography (…
[HTML][HTML] Pharmacological characterisation of CR6086, a potent prostaglandin E2 receptor 4 antagonist, as a new potential disease-modifying anti-rheumatic drug
…, M Perrella, O Letari, E Di Luccio, M Colovic… - Arthritis Research & …, 2018 - Springer
Background Prostaglandin E 2 (PGE 2 ) acts via its EP4 receptor as a cytokine amplifier (eg,
interleukin [IL]-6) and induces the differentiation and expansion of inflammatory T-helper (Th…
interleukin [IL]-6) and induces the differentiation and expansion of inflammatory T-helper (Th…
Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation, and Structure−Activity Relationships
…, T Mennini, C Fracasso, M Colovic… - Journal of medicinal …, 2009 - ACS Publications
The synthesis and the biological characterization of novel highly selective pyrroloquinoxaline
5-HT 3 receptor (5-HT 3 R) ligands are described. In functional and in vivo biological …
5-HT 3 receptor (5-HT 3 R) ligands are described. In functional and in vivo biological …
Comparative Evaluation of [18F] 5-Fluoroaminosuberic Acid and (4S)-4-3-[18F] fluoropropyl)-l-Glutamate as System–Targeting Radiopharmaceuticals
M Colovic, H Yang, L Southcott… - Journal of Nuclear …, 2023 - Soc Nuclear Med
System x C − is an appealing biomarker for targeting oxidative stress with oncologic PET
imaging and can serve as an alternative PET biomarker to other metabolic indicators. In this …
imaging and can serve as an alternative PET biomarker to other metabolic indicators. In this …
Synthesis and evaluation of bifunctional tetrahydroxamate chelators for labeling antibodies with 89Zr for imaging with positron emission tomography
Two novel bifunctional tetrahydroxamate chelators 3 and 4 were synthesized and evaluated
for labeling antibodies with 89 Zr for positron emission tomography imaging. Compared to …
for labeling antibodies with 89 Zr for positron emission tomography imaging. Compared to …