The effect of lipophilicity on the protein binding and blood cell uptake of some acidic drugs
M Lázníček, A Lázníčková - Journal of pharmaceutical and biomedical …, 1995 - Elsevier
Quantitative relationships between lipophilicity (characterized by the octanol-water partition
coefficient) and binding to both human plasma proteins and blood cells have been studied in …
coefficient) and binding to both human plasma proteins and blood cells have been studied in …
Electrospinning of diosmin from aqueous solutions for improved dissolution and oral absorption
P Vrbata, P Berka, D Stránská, P Doležal… - International journal of …, 2014 - Elsevier
A nanofibrous membrane carrier for nearly water insoluble drug diosmin was formulated.
The aim of this study was to evaluate the drug release and dissolution properties in an …
The aim of this study was to evaluate the drug release and dissolution properties in an …
Preclinical pharmacokinetics of radiolabeled hyaluronan
M Laznicek, A Laznickova, D Cozikova… - Pharmacological …, 2012 - Springer
Background Hyaluronan (HYA) is a high molecular weight glucosaminoglycan with a great
perspective for medical applications. Because HYA is widespread in the body, it is difficult to …
perspective for medical applications. Because HYA is widespread in the body, it is difficult to …
Protein interactions with HER-family receptors can have different characteristics depending on the hosting cell line
…, V Tolmachev, M Laznicek… - International …, 2012 - spandidos-publications.com
Cell lines are common model systems in the development of therapeutic proteins and in the
research on cellular functions and dysfunctions. In this field, the protein interaction assay is a …
research on cellular functions and dysfunctions. In this field, the protein interaction assay is a …
[HTML][HTML] 2,3-Dihydro-1H-cyclopenta[b]quinoline Derivatives as Acetylcholinesterase Inhibitors—Synthesis, Radiolabeling and Biodistribution
P Szymański, A Lázničková, M Lázniček… - International Journal of …, 2012 - mdpi.com
In the present study we describe the synthesis and biological assessment of new tacrine
analogs in the course of inhibition of acetylcholinesterase. The obtained molecules were …
analogs in the course of inhibition of acetylcholinesterase. The obtained molecules were …
Radiolabeling of PAMAM dendrimers conjugated to a pyridine-N-oxide DOTA analog with 111In: Optimization of reaction conditions and biodistribution
V Biricová, A Lázničková, M Lázníček… - … of pharmaceutical and …, 2011 - Elsevier
Polyamidoamine dendrimers (PAMAMs) of generations 1 (G1) and 4 (G4) were conjugated
with a bifunctional pyridine-N-oxide DOTA analog, 10-[(4-carboxy-1-oxidopyridin-2-yl)methyl]…
with a bifunctional pyridine-N-oxide DOTA analog, 10-[(4-carboxy-1-oxidopyridin-2-yl)methyl]…
Preclinical Evaluation of 177Lu-Nimotuzumab: A Potential Tool for Radioimmunotherapy of Epidermal Growth Factor Receptor–Overexpressing Tumors
…, KE Henke, A Laznickova, M Laznicek… - Cancer Biotherapy & …, 2011 - liebertpub.com
Background: The humanized monoclonal antibody Nimotuzumab (h-R3) has demonstrated
an exceptional and better clinical profile than other monoclonal antibodies for …
an exceptional and better clinical profile than other monoclonal antibodies for …
[PDF][PDF] Pharmacokinetics and renal handling of 99mTc-labeled peptides
F Trejtnar, M Laznicek, A Laznickova… - Journal of Nuclear …, 2000 - Soc Nuclear Med
MATERIALS AND METHODS Chemicals Three peptides, acetyl-N-Gly-Gly-Cys-Gly (AGGCG),
acetyl-N Ser-Ser-Cys-Gly (ASSCG), and acetyl-N-Gly-Gly-Cys-Lys (AGGCL), were …
acetyl-N Ser-Ser-Cys-Gly (ASSCG), and acetyl-N-Gly-Gly-Cys-Lys (AGGCL), were …
A comparison of in vitro methods for determining the membrane receptor expression in cell lines
Z Novy, P Barta, J Mandikova, M Laznicek… - Nuclear medicine and …, 2012 - Elsevier
INTRODUCTION: Determining the number of expressed receptors per cell (NRPC) in cell
lines is an important prerequisite for many experimental procedures in biomedical research. …
lines is an important prerequisite for many experimental procedures in biomedical research. …
In vitro evaluation of the monoclonal antibody 64Cu-IgG M75 against human carbonic anhydrase IX and its in vivo imaging
A Čepa, J Ráliš, V Král, M Paurová, J Kučka… - Applied Radiation and …, 2018 - Elsevier
Specific oncology diagnostics requires new types of the selective radiopharmaceuticals,
particularly those suitable for the molecular PET imaging. The aim of this work is to present a …
particularly those suitable for the molecular PET imaging. The aim of this work is to present a …