In-house cyclotron production of high-purity Tc-99m and Tc-99m radiopharmaceuticals

…, F Zagni, A Corazza, L Uccelli, M Pasquali… - Applied Radiation and …, 2018 - Elsevier
In the last years, the technology for producing the important medical radionuclide technetium-99m
by cyclotrons has become sufficiently mature to justify its introduction as an alternative …

[HTML][HTML] LARAMED: a laboratory for radioisotopes of medical interest

…, G Keppel, P Martini, M Maggiore, L Mou, M Pasquali… - Molecules, 2018 - mdpi.com
The widespread availability of novel radioactive isotopes showing nuclear characteristics
suitable for diagnostic and therapeutic applications in nuclear medicine (NM) has experienced …

A solvent-extraction module for cyclotron production of high-purity technetium-99m

…, A Boschi, G Cicoria, L Uccelli, M Pasquali… - Applied Radiation and …, 2016 - Elsevier
The design and fabrication of a fully-automated, remotely controlled module for the
extraction and purification of technetium-99m (Tc-99m), produced by proton bombardment of …

Production of 67Cu by enriched 70Zn targets: first measurements of formation cross sections of 67Cu, 64Cu, 67Ga, 66Ga, 69mZn and 65Zn in interactions of 70Zn with …

G Pupillo, L Mou, P Martini, M Pasquali, A Boschi… - Radiochimica …, 2020 - degruyter.com
Despite its insufficient availability, Copper-67 is currently attracting much attention for its
enormous potential for cancer therapy as theranostic radionuclide. This work aims to accurately …

Recent achievements in Tc-99m radiopharmaceutical direct production by medical cyclotrons

A Boschi, P Martini, M Pasquali… - Drug development and …, 2017 - Taylor & Francis
99m Tc is the most commonly used radionuclide in the field of diagnostic imaging, a
noninvasive method intended to diagnose a disease, assess the disease state and monitor the …

Production of 47Sc with natural vanadium targets: results of the PASTA project

…, A Fontana, F Haddad, P Martini, M Pasquali… - … of Radioanalytical and …, 2019 - Springer
The goal of PASTA project (acronym for production with accelerator of 47 Sc for theranostic
applications) is the determination of excitation functions associated to several nuclear …

[HTML][HTML] Psychostimulant effect of the synthetic cannabinoid JWH-018 and AKB48: behavioral, neurochemical, and dopamine transporter scan imaging studies in mice

…, S Bilel, I Canazza, G Di Domenico, M Pasquali… - Frontiers in …, 2017 - frontiersin.org
JWH-018 and AKB48 are two synthetic cannabinoids (SCBs) belonging to different structural
classes and illegally marketed as incense, herbal preparations, or chemical supply for …

[HTML][HTML] 14 MeV Neutrons for 99Mo/99mTc Production: Experiments, Simulations and Perspectives

…, A Fazio, S Loreti, P Martini, G Pagano, M Pasquali… - Molecules, 2018 - mdpi.com
Background: the gamma-emitting radionuclide Technetium-99m ( 99m Tc) is still the workhorse
of Single Photon Emission Computed Tomography (SPECT) as it is used worldwide for …

Preparation and first biological evaluation of novel Re-188/Tc-99m peptide conjugates with substance-P

K Smilkov, E Janevik, R Guerrini, M Pasquali… - Applied Radiation and …, 2014 - Elsevier
Introduction New 188 Re and 99m Tc peptide conjugates with substance- P (SP) were prepared
and biologically evaluated. The radiopharmaceuticals have been labelled with the [M≡…

Automated preparation of Re-188 lipiodol for the treatment of hepatocellular carcinoma

L Uccelli, M Pasquali, A Boschi, M Giganti… - Nuclear Medicine and …, 2011 - Elsevier
The iodinated oil lipiodol is commonly used as a carrier for in situ delivery of drugs or radioactivity
to hepatic tumors. Recently, we reported a new kit formulation for high-activity labeling …