In vivo visualization of tau deposits in corticobasal syndrome by 18F-THK5351 PET

…, R Oshima, S Yoshida, J Kobayashi, M Ezura… - Neurology, 2016 - AAN Enterprises
Objective: To determine whether 18 F-THK5351 PET can be used to visualize tau deposits in
brain lesions in live patients with corticobasal syndrome (CBS). Methods: We evaluated the …

18F-SMBT-1: a selective and reversible PET tracer for monoamine oxidase-B imaging

R Harada, Y Hayakawa, M Ezura… - Journal of Nuclear …, 2021 - Soc Nuclear Med
Reactive astrocytes play a key role in the pathogenesis of various neurodegenerative
diseases. Monoamine oxidase-B (MAO-B) is one of the promising targets for the imaging of …

Parkinson's disease-linked DNAJC13 mutation aggravates alpha-synuclein-induced neurotoxicity through perturbation of endosomal trafficking

…, A Ido-Fujibayashi, K Sekiguchi, M Ezura… - Human Molecular …, 2018 - academic.oup.com
Mutations in DNAJC13 gene have been linked to familial form of Parkinson’s disease (PD)
with Lewy pathology. DNAJC13 is an endosome-related protein and believed to regulate …

[HTML][HTML] 18F-THK5351 Positron Emission Tomography Imaging in Neurodegenerative Tauopathies

M Ezura, A Kikuchi, N Okamura, A Ishiki… - Frontiers in Aging …, 2021 - frontiersin.org
Introduction: We aimed to determine whether in vivo tau deposits and monoamine oxidase
B (MAO-B) detection using 18 F-THK5351 positron emission tomography (PET) can assist in …

Extracellular α‐synuclein enters dopaminergic cells by modulating flotillin‐1–assisted dopamine transporter endocytosis

…, I Kawahata, T Yamakuni, M Ezura… - The FASEB …, 2019 - Wiley Online Library
The neuropathological hallmarks of Parkinson's disease (PD) include the appearance of α‐synuclein
(α‐SYN)‐positive Lewy bodies (LBs) and the loss of catecholaminergic neurons. …

Preclinical characterization of the Tau PET Tracer [18F] SNFT-1: comparison of tau PET tracers

…, Y Yokoyama, Y Du, K Kudo, M Ezura… - Journal of Nuclear …, 2023 - Soc Nuclear Med
Tau PET tracers are expected to be sufficiently sensitive to track the progression of age-related
tau pathology in the medial temporal cortex. The tau PET tracer N-(4-[ 18 F]fluoro-5-…

High prevalence of serum anti-NH2-terminal of α-enolase antibodies in patients with multiple system atrophy and corticobasal syndrome

…, A Matsunaga, M Ikawa, T Nakamura, M Ezura… - Journal of …, 2021 - Springer
Background Hashimoto’s encephalopathy with serum anti-NH 2 -terminal of α-enolase (NAE)
antibodies occasionally displays clinical symptoms such as cerebellar ataxia and …

[HTML][HTML] Logopenic aphasia due to Lewy body disease dramatically improved with donepezil

K Kakinuma, T Baba, M Ezura, K Endo, Y Saito… - …, 2020 - ncbi.nlm.nih.gov
Logopenic progressive aphasia (LPA) is a major subtype of primary progressive aphasia (PPA),
characterized by frequent word-finding pauses and impaired sentence repetition [1]. …

Sortilin acts as an endocytic receptor for α‐synuclein fibril

…, Y Kawata, T Nakamura, K Sato, M Ezura… - The FASEB …, 2023 - Wiley Online Library
Cell‐to‐cell spreading of misfolded α‐synuclein (αSYN) is supposed to play a key role in
the pathological progression of Parkinson's disease (PD) and other synucleinopathies. …

A Case of Corticobasal Syndrome and Posterior Cortical Atrophy With Biomarkers of Alzheimer Disease

Y Sugimura, T Baba, M Ezura, A Kikuchi… - Alzheimer Disease & …, 2023 - journals.lww.com
Corticobasal syndrome is a clinical entity characterized by asymmetric akinetic rigidity and a
variety of higher cortical dysfunction. Predicting background pathology of corticobasal …