Polyketides from actinomycete bacteria provide the basis for many valuable medicines, so
engineering genes for their biosynthesis to produce variant molecules holds promise for drug …

An Escherichia coli–actinomycete shuttle vector, pCJW93, was constructed which places
cloned genes under the control of the thiostrepton-inducible tip promoter from Streptomyces …

Radioimmunotherapy and nuclear imaging (immuno-PET/SPECT) of cancer with radiometal-labeled
antibody fragments or peptides is hampered by low tumor-to-kidney ratios because …

Optimal PET imaging of tumors with radiolabeled engineered antibodies requires, among
other parameters, matching blood clearance and tumor uptake with the half-life of the …

Through protein engineering and a novel pegylation strategy, a diabody specific to tumor-associated
glycoprotein 72 (TAG-72)(PEG-AVP0458) has been created to optimize …

In this study, we compared the tumor-targeting properties, therapeutic efficacy, and tolerability
of the humanized anti-CAIX antibody (hG250) labeled with either the α-emitter actinium-…

Prostate-specific membrane antigen (PSMA) is a carboxypeptidase that is overexpressed in
prostate cancer and is an excellent candidate for targeted diagnostic imaging and therapy. …

Radiolabeled derivatives of Tyr 3 -octreotide and Tyr 3 -octreotate, synthetic analogues of
the peptide hormone somatostatin, can be used for positron emission tomography (PET) …

This paper will present an approach for improving the reliability of mooring systems for ships
and mobile offshore drilling units. An analysis of damage surveys indicates that the most …

Multimeric antibody fragments, particularly dimers (diabodies), trimers (triabodies), and
tetramers (tetrabodies) of single-chain Fv molecules (scFv), provide high avidity through …