User profiles for Michael P. Murphy
 | Michael P MurphyMRC Mitochondrial BIology Unit, University of Cambridge Verified email at mrc-mbu.cam.ac.uk Cited by 76340 |
How mitochondria produce reactive oxygen species
MP Murphy - Biochemical journal, 2009 - portlandpress.com
The production of ROS (reactive oxygen species) by mammalian mitochondria is important
because it underlies oxidative damage in many pathologies and contributes to retrograde …
because it underlies oxidative damage in many pathologies and contributes to retrograde …
[PDF][PDF] Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages
Activated macrophages undergo metabolic reprogramming, which drives their pro-inflammatory
phenotype, but the mechanistic basis for this remains obscure. Here, we demonstrate …
phenotype, but the mechanistic basis for this remains obscure. Here, we demonstrate …
Selective targeting of an antioxidant to mitochondria
…, CM Porteous, CV Coulter, MP Murphy - European Journal of …, 1999 - Wiley Online Library
Mitochondrial oxidative damage contributes significantly to a range of human disorders,
including neurodegenerative diseases, ischaemia‐reperfusion injury and ageing‐associated …
including neurodegenerative diseases, ischaemia‐reperfusion injury and ageing‐associated …
Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes
Hyperglycemia causes many of the pathological consequences of both type 1 and type 2
diabetes. Much of this damage is suggested to be a consequence of elevated production of …
diabetes. Much of this damage is suggested to be a consequence of elevated production of …
Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
‘Reactive oxygen species’ (ROS) is a generic term that defines a wide variety of oxidant
molecules with vastly different properties and biological functions that range from signalling to …
molecules with vastly different properties and biological functions that range from signalling to …
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
Ischaemia-reperfusion injury occurs when the blood supply to an organ is disrupted and then
restored, and underlies many disorders, notably heart attack and stroke. While reperfusion …
restored, and underlies many disorders, notably heart attack and stroke. While reperfusion …
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
…, CU Pietrzik, KA Findlay, TE Smith, MP Murphy… - Nature, 2001 - nature.com
Epidemiological studies have documented a reduced prevalence of Alzheimer's disease
among users of nonsteroidal anti-inflammatory drugs (NSAIDs) 1 , 2 , 3 , 4 , 5 . It has been …
among users of nonsteroidal anti-inflammatory drugs (NSAIDs) 1 , 2 , 3 , 4 , 5 . It has been …
[HTML][HTML] Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo
Multiple roles of reactive oxygen species (ROS) and their consequences for health and
disease are emerging throughout biological sciences. This development has led researchers …
disease are emerging throughout biological sciences. This development has led researchers …
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
The endogenous metabolite itaconate has recently emerged as a regulator of macrophage
function, but its precise mechanism of action remains poorly understood 1 , 2 , 3 . Here we …
function, but its precise mechanism of action remains poorly understood 1 , 2 , 3 . Here we …
Targeting antioxidants to mitochondria by conjugation to lipophilic cations
Mitochondrial oxidative damage contributes to a range of degenerative diseases. Consequently,
the selective inhibition of mitochondrial oxidative damage is a promising therapeutic …
the selective inhibition of mitochondrial oxidative damage is a promising therapeutic …