Background Dabrafenib is an inhibitor of BRAF kinase that is selective for mutant BRAF. We
aimed to assess its safety and tolerability and to establish a recommended phase 2 dose in …

Background Nivolumab monotherapy and combination nivolumab plus ipilimumab increase
proportions of patients achieving a response and survival versus ipilimumab in patients with …

… By situating the closet in different locations and at different spatial scales, Michael P. Brown
shows how its iterations have implications for a wide array of contemporary social theories …

This book uses an ethnographic study of one gay community's responses to AIDS to illustrate
a radical democratic understanding of citizenship in contemporary society. Analyzing …

Immune modulation has become a central element in many cancer treatments, and T cells
genetically engineered to express chimeric antigen receptors (CAR) may provide a new …

Antibody-dependent cellular cytotoxicity (ADCC) is a major mechanism of action of therapeutic
monoclonal antibodies (mAbs) such as cetuximab, rituximab and trastuzumab. Fc gamma …

Chimeric antigen receptor (CAR) T cells have shown great promise in the treatment of
hematologic malignancies but more variable results in the treatment of solid tumors and the …

Antibody drug conjugates (ADCs) employ the exquisite specificity of tumour-specific monoclonal
antibodies (mAb) for the targeted delivery of highly potent cytotoxic drugs to the tumour …

Prudentius' Contra Symmachum contains a refutation of Symmachus' plea for the retaining
of the altar of Victory in the Senate house at Rome which had been removed in 357 and then, …

We present a synthesis of clinical, neuropathological, and biological details of the National
Institutes of Health series of 300 experimentally transmitted cases of spongiform …