Regional profiles of the candidate tau PET ligand 18 F-AV-1451 recapitulate key features of Braak histopathological stages
…, P Yu, BB Miller, S Shcherbinin, J Dickson, M Navitsky… - Brain, 2016 - academic.oup.com
See Thal and Vandenberghe (doi: 10.1093/brain/aww057 ) for a scientific commentary on this
article. Post-mortem Braak staging of neurofibrillary tau tangle topographical distribution is …
article. Post-mortem Braak staging of neurofibrillary tau tangle topographical distribution is …
Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition
MJ Pontecorvo, MD Devous Sr, M Navitsky, M Lu… - Brain, 2017 - academic.oup.com
The advent of tau-targeted positron emission tomography tracers such as flortaucipir ( 18 F-AV-1451,
also known as 18 F-T807) have made it possible to investigate the sequence of …
also known as 18 F-T807) have made it possible to investigate the sequence of …
Positron emission tomography imaging with [18F] flortaucipir and postmortem assessment of Alzheimer disease neuropathologic changes
Importance Positron emission tomography (PET) may increase the diagnostic accuracy and
confirm the underlying neuropathologic changes of Alzheimer disease (AD). Objective To …
confirm the underlying neuropathologic changes of Alzheimer disease (AD). Objective To …
[HTML][HTML] Tau positron-emission tomography in former national football league players
Background Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that
has been associated with a history of repetitive head impacts. The neuropathological …
has been associated with a history of repetitive head impacts. The neuropathological …
A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer's disease dementia
MJ Pontecorvo, MD Devous, I Kennedy, M Navitsky… - Brain, 2019 - academic.oup.com
The advent of tau-targeted PET tracers such as flortaucipir ( 18 F) (flortaucipir, also known
as 18 F-AV-1451 or 18 F-T807) have made it possible to investigate the sequence of …
as 18 F-AV-1451 or 18 F-T807) have made it possible to investigate the sequence of …
Standardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale
M Navitsky, AD Joshi, I Kennedy… - Alzheimer's & …, 2018 - Wiley Online Library
Introduction Klunk et al. recently proposed a means of standardizing quantitation of amyloid
burden from positron emission tomography scans to a common Centiloid scale, and we …
burden from positron emission tomography scans to a common Centiloid scale, and we …
Kinetics of the tau PET tracer 18F-AV-1451 (T807) in subjects with normal cognitive function, mild cognitive impairment, and Alzheimer disease
…, AJ Schwarz, A Joshi, M Navitsky… - Journal of Nuclear …, 2016 - Soc Nuclear Med
We report kinetic modeling results of dynamic acquisition data from 0 to 100 min after injection
with the tau PET tracer 18 F-AV-1451 in 19 subjects. Methods: Subjects were clinically …
with the tau PET tracer 18 F-AV-1451 in 19 subjects. Methods: Subjects were clinically …
Flortaucipir F 18 quantitation using parametric estimation of reference signal intensity
…, MD Devous, I Kennedy, M Navitsky… - Journal of Nuclear …, 2018 - Soc Nuclear Med
PET imaging of tau pathology in Alzheimer disease may benefit from the use of white matter
reference regions. These regions have shown reduced variability compared with …
reference regions. These regions have shown reduced variability compared with …
Test–retest reproducibility for the tau PET imaging agent flortaucipir F 18
MD Devous, AD Joshi, M Navitsky… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Alzheimer disease (AD) is characterized by β-amyloid (Aβ) plaques and tau neurofibrillary
tangles. There are several PET imaging biomarkers for Aβ including 11 C-PiB and 18 F-…
tangles. There are several PET imaging biomarkers for Aβ including 11 C-PiB and 18 F-…
[HTML][HTML] Comparison of regional flortaucipir PET with quantitative tau immunohistochemistry in three subjects with Alzheimer's disease pathology: a clinicopathological …
…, TJ Montine, AK Arora, MD Devous, M Navitsky… - Ejnmmi Research, 2020 - Springer
Background The objective of this study was to make a quantitative comparison of flortaucipir
PET retention with pathological tau and β-amyloid across a range of brain regions at autopsy…
PET retention with pathological tau and β-amyloid across a range of brain regions at autopsy…