The unique metabolic demands of cancer cells underscore potentially fruitful opportunities
for drug discovery in the era of precision medicine. However, therapeutic targeting of cancer …

Potentiating anti-tumor immunity by inducing tumor inflammation and T cell-mediated responses
are a promising area of cancer therapy. Immunomodulatory agents that promote these …

The Dominantly Inherited Alzheimer Network (DIAN) is an international collaboration studying
autosomal dominant Alzheimer disease (ADAD). ADAD arises from mutations occurring in …

Molecular imaging is an attractive modality that has been widely employed in many aspects
of biomedical research; especially those aimed at the early detection of diseases such as …

Purpose Non-invasive imaging is central to hepatocellular carcinoma (HCC) diagnosis;
however, conventional modalities are limited by smaller tumors and other chronic diseases that …

Purpose Alanine-serine-cysteine transporter 2 (ASCT2) expression has been demonstrated
as a promising lung cancer biomarker. (2S,4R)-4-[ 18 F]Fluoroglutamine (4-[ 18 F]fluoro-Gln) …

Focused library synthesis and structure–activity relationship development of 5,6,7-substituted
pyrazolopyrimidines led to the discovery of 2-(5,7-diethyl-2-(4-(2-fluoroethoxy)phenyl)…

The current utilization of positron emission tomography (PET) imaging is limited due to the
high costs associated with production facility start-up and operations; subsequently, there has …

Off-target binding of [ 18 F]flortaucipir (FTP) can complicate quantitative PET analyses. An
underdiscussed off-target region is the skull. Here, we characterize how often FTP skull …

Background: Alpha-particle-emitting radiotherapies are of great interest for the treatment of
disseminated cancer. Actinium-225 ( 225 Ac) produces four α-particles through its decay and …