Rationale This review provides insight for the judicious selection of nicotine dose ranges and
routes of administration for in vivo studies. The literature is replete with reports in which a …

The identity of nicotinic receptor subtypes sufficient to elicit both the acute and chronic effects
of nicotine dependence is unknown. We engineered mutant mice with α4 nicotinic subunits …

Nicotinic acetylcholine receptors (nACh receptors2) in jawed vertebrates are prototypical
members of the multisubunit, neurotransmitter-gated superfamily of ion channels (ionotropic …

DBA mice were chronically treated with nicotine by continuous intravenous infusion of 4.0
mg/kg/hr for 10 d. Drug-treated mice were tolerant to the acute effects of nicotine on locomotor …

Genetic variation in CHRNA5, the gene encoding the α5 nicotinic acetylcholine receptor
subunit, increases vulnerability to tobacco addiction and lung cancer, but the underlying …

Chronic nicotine administration in animal models evokes a dose-dependent increase in brain
nicotinic receptor numbers. Genetically determined variability in nicotinic receptor number …

Pharmacological evaluation of nicotine-stimulated dopamine release from striatum has yielded
data consistent with activation of a single population of nicotinic acetylcholine receptors (…

Previous studies have suggested that an abnormality in neuronal nicotinic acetylcholine
receptor expression or function may be involved in the neuropathophysiology of schizophrenia. …

This study establishes that presynaptic nicotinic receptors modulate dopamine release in the
mouse striatum. Nicotinic agonists elicit a dose‐dependent increase in the release of [ 3 H]…

Understanding effects of chronic nicotine requires identifying the neurons and synapses
whose responses to nicotine itself, and to endogenous acetylcholine, are altered by continued …