Standard treatment for neoplastic meningitis requires frequent intrathecal (IT) injections of
chemotherapy and is only modestly effective. DepoCyt is a sustained-release formulation of …

BACKGROUND Detection of malignant cells on cytologic examination of the cerebrospinal
fluid (CSF) is the diagnostic gold standard for leptomeningeal carcinomatosis. The absence …

PURPOSE: To evaluate the efficacy and safety of a slow-release formulation of cytarabine (DepoCyt;
Chiron Corp, Emeryville, CA, and Skye Pharma, Inc, San Diego, CA) that maintains …

The serum and cerebrospinal fluid (CSF) of 8 women with ataxia, 6 of whom also had eye
movement abnormalities believed to be opsoclonus, were found to contain a highly specific …

Concurrent temozolomide (TMZ) and radiotherapy is the new standard of care for patients
with newly diagnosed glioblastoma. In 51 consecutive patients treated according to this …

When radiation is used to treat nervous system cancer, exposure of adjacent normal nervous
system tissue is unavoidable, and radiation-induced injury may occur. Acute injury is …

PURPOSE Standard treatments for neoplastic meningitis are only modestly effective and are
associated with significant morbidity. Isolated reports suggest that concurrent systemic and …

Tumor necrosis commonly exists and predicts poor prognoses in many cancers. Although it
is thought to result from chronic ischemia, the underlying nature and mechanisms driving the …

Background: Somatostatin receptors, especially the sst2A subtype, are present on most
meningiomas. The addition of somatostatin inhibits meningioma growth in vitro in some studies. …

BACKGROUND: Life‐threatening illness creates severe stress that may result in marital
discord, separation, or divorce and may adversely impact treatment, quality of life, and survival. …