User profiles for Michael Devous
 | Michael DevousVice President, Avid Radiopharmaceuticals Verified email at avidrp.com Cited by 19662 |
Four distinct trajectories of tau deposition identified in Alzheimer's disease
…, Y Iturria-Medina, MJ Pontecorvo, MD Devous… - Nature medicine, 2021 - nature.com
Alzheimer’s disease (AD) is characterized by the spread of tau pathology throughout the
cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals, …
cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals, …
The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET
…, JC Price, TL Benzinger, MD Devous Sr… - Alzheimer's & …, 2015 - Elsevier
Although amyloid imaging with PiB-PET ([C-11]Pittsburgh Compound-B positron emission
tomography), and now with F-18-labeled tracers, has produced remarkably consistent …
tomography), and now with F-18-labeled tracers, has produced remarkably consistent …
Regional profiles of the candidate tau PET ligand 18 F-AV-1451 recapitulate key features of Braak histopathological stages
…, J Dickson, M Navitsky, AD Joshi, MD Devous Sr… - Brain, 2016 - academic.oup.com
See Thal and Vandenberghe (doi: 10.1093/brain/aww057 ) for a scientific commentary on this
article. Post-mortem Braak staging of neurofibrillary tau tangle topographical distribution is …
article. Post-mortem Braak staging of neurofibrillary tau tangle topographical distribution is …
Accuracy of tau positron emission tomography as a prognostic marker in preclinical and prodromal Alzheimer disease: a head-to-head comparison against amyloid …
Importance Tau positron emission tomography (PET) tracers have proven useful for the
differential diagnosis of dementia, but their utility for predicting cognitive change is unclear. …
differential diagnosis of dementia, but their utility for predicting cognitive change is unclear. …
Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition
MJ Pontecorvo, MD Devous Sr, M Navitsky, M Lu… - Brain, 2017 - academic.oup.com
The advent of tau-targeted positron emission tomography tracers such as flortaucipir ( 18 F-AV-1451,
also known as 18 F-T807) have made it possible to investigate the sequence of …
also known as 18 F-T807) have made it possible to investigate the sequence of …
A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
…, K Martin-Cook, M DeVous… - Proceedings of the …, 2010 - National Acad Sciences
A recently identified variant within the fat mass and obesity-associated (FTO) gene is carried
by 46% of Western Europeans and is associated with an ~1.2 kg higher weight, on average, …
by 46% of Western Europeans and is associated with an ~1.2 kg higher weight, on average, …
Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional–executive network function in Alzheimer's disease
…, L deToledo-Morrell, M DeVous… - Proceedings of the …, 2010 - National Acad Sciences
The ε4 allele of the apolipoprotein E (APOE) gene is the major genetic risk factor for
Alzheimer’s disease (AD), but limited work has suggested that APOE genotype may modulate …
Alzheimer’s disease (AD), but limited work has suggested that APOE genotype may modulate …
Brain functional localization: a survey of image registration techniques
…, N Kehtarnavaz, R Briggs, M Devous… - IEEE transactions on …, 2007 - ieeexplore.ieee.org
Functional localization is a concept which involves the application of a sequence of
geometrical and statistical image processing operations in order to define the location of brain …
geometrical and statistical image processing operations in order to define the location of brain …
Amyloid-β assessed by florbetapir F 18 PET and 18-month cognitive decline: a multicenter study
Objectives: Florbetapir F 18 PET can image amyloid-β (Aβ) aggregates in the brains of living
subjects. We prospectively evaluated the prognostic utility of detecting Aβ pathology using …
subjects. We prospectively evaluated the prognostic utility of detecting Aβ pathology using …
Positron emission tomography imaging with [18F] flortaucipir and postmortem assessment of Alzheimer disease neuropathologic changes
AS Fleisher, MJ Pontecorvo, MD Devous, M Lu… - JAMA …, 2020 - jamanetwork.com
Importance Positron emission tomography (PET) may increase the diagnostic accuracy and
confirm the underlying neuropathologic changes of Alzheimer disease (AD). Objective To …
confirm the underlying neuropathologic changes of Alzheimer disease (AD). Objective To …