Chimeric antigen receptor (CAR) T cells have demonstrated promising efficacy, particularly
in hematologic malignancies. One challenge regarding CAR T cells in solid tumors is the …

Immunologic responses to anti-PD-1 therapy in melanoma patients occur rapidly with
pharmacodynamic T cell responses detectable in blood by 3 weeks. It is unclear, however, …

Positron emission tomography (PET) is a radiotracer imaging method that yields quantitative
images of regional in vivo biology and biochemistry. PET, now used in conjunction with …

Advances in the treatment of metastatic melanoma have improved responses and survival.
However, many patients continue to experience resistance or toxicity to treatment, …

… Michael D. Farwell receives consulting fees and grant/research support from ImaginAb.
Matthew D. Hellmann has equity in Shattuck Labs, Immunai, and Arcus, and he has a patent filed …

BACKGROUND. Poly(ADP-ribose) polymerase (PARP) inhibitors are effective in a broad
population of patients with ovarian cancer; however, resistance caused by low enzyme …

… PET imaging studies designed to evaluate the postsynaptic dopamine D 2 receptor have
shown that striatal dopamine D 2 receptor binding is intact in PD, but it can be reduced in MSA …

Background We conducted a phase I trial evaluating pembrolizumab+hypofractionated
radiotherapy (HFRT) for patients with metastatic cancers. Methods There were two strata (12 …

Cell-based therapeutics have considerable promise across diverse medical specialties;
however, reliable human imaging of the distribution and trafficking of genetically engineered …

Importance Individualized cancer treatment, tailored to a particular patient and the tumor’s
biological features (precision oncology), requires a detailed knowledge of tumor biology. …