Multiple sclerosis (MS) is a complex trait in which allelic variation in the MHC class II region
exerts the single strongest effect on genetic risk. Epidemiological data in MS provide strong …

Single-molecule real-time (SMRT) DNA sequencing allows the systematic detection of
chemical modifications such as methylation but has not previously been applied on a genome-…

A zebrafish heart can fully regenerate after amputation of up to 20% of its ventricle. During
this process, newly formed coronary blood vessels revascularize the regenerating tissue. The …

PURPOSE: To assess the utility of FDG-PET in anal cancer for staging and impact on
radiotherapy planning (RTP), response and detection of recurrent disease. METHODS AND …

The impact of apolipoprotein E ε4 (APOE4), the strongest genetic risk factor for Alzheimer's
disease (AD), on human brain cellular function remains unclear. Here, we investigated the …

As a Mendelian neurodegenerative disorder, the genetic risk of Huntington's disease (HD)
is conferred entirely by an HTT CAG repeat expansion whose length is the primary …

Serotonin (5-HT) modulates synaptic efficacy in the nervous system of vertebrates and
invertebrates. In the nematode Caenorhabditis elegans, many behaviors are regulated by 5-HT …

Mycobacterium tuberculosis, which causes tuberculosis, remains a major human public health
threat. This is largely due to a sizeable reservoir of latently infected individuals, who may …

Variable, glutamine-encoding, CAA interruptions indicate that a property of the uninterrupted
HTT CAG repeat sequence, distinct from the length of huntingtin's polyglutamine segment, …

A comprehensive genetics-based precision medicine strategy to selectively and permanently
inactivate only mutant, not normal allele, could benefit many dominantly inherited disorders…