User profiles for Michael C. Chang

Michael C Chang

Genentech, Inc.
Verified email at gene.com
Cited by 1328

Relationship of early hyperglycemia to mortality in trauma patients

…, PD Kilgo, JW Meredith, MC Chang - Journal of Trauma …, 2004 - journals.lww.com
Methods: The records of all patients admitted to the ICU over a 2-year period at a Level I
trauma center were reviewed for age, injury severity scores (ISS), admission Glasgow Coma …

Diagnosis and initial management of blunt pancreatic trauma: guidelines from a multiinstitutional review

EL Bradley III, PR Young Jr, MC Chang, JE Allen… - Annals of …, 1998 - journals.lww.com
Objective The authors' objective was to resolve the current controversies surrounding the
diagnosis and management of blunt pancreatic trauma (BPT). Summary Background Data The …

Prospective evaluation of vacuum-assisted fascial closure after open abdomen: planned ventral hernia rate is substantially reduced

…, JW Meredith, JC Johnson, MC Chang - Annals of surgery, 2004 - journals.lww.com
Objective: The goal of this report is to examine the success of vacuum-assisted fascial
closure (VAFC) under a carefully applied protocol in abdominal closure after open abdomen. …

External fixation or arteriogram in bleeding pelvic fracture: initial therapy guided by markers of arterial hemorrhage

…, E Mansell, JW Meredith, MC Chang - Journal of Trauma …, 2003 - journals.lww.com
Background Bleeding pelvic fractures (BPF) carry mortality as high as 60%, yet controversy
remains over optimal initial management. Some base initial intervention on fracture pattern, …

The spectrum of blunt injury to the carotid artery: a multicenter perspective

…, MC Chang, GT Trevasani, C Aprahamian… - Journal of Trauma …, 1994 - journals.lww.com
The relative infrequency of blunt carotid artery trauma prompted a multicenter review to
determine the spectrum of injuries, treatment strategies, and neurologic outcome. During a six-…

Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons

MC Chang, JM Park, KA Pelkey, HL Grabenstatter… - Nature …, 2010 - nature.com
Homeostatic synaptic scaling alters the strength of synapses to compensate for prolonged
changes in network activity and involves both excitatory and inhibitory neurons. The immediate…

[PDF][PDF] Complement C3 is activated in human AD brain and is required for neurodegeneration in mouse models of amyloidosis and tauopathy

…, H Ngu, O Foreman, WJ Meilandt, J Elstrott, MC Chang… - Cell reports, 2019 - cell.com
Complement pathway overactivation can lead to neuronal damage in various neurological
diseases. Although Alzheimer's disease (AD) is characterized by β-amyloid plaques and tau …

Estimation of intra-abdominal pressure by bladder pressure measurement: validity and methodology

MA Fusco, RS Martin, MC Chang - Journal of Trauma and Acute …, 2001 - journals.lww.com
Background Increased intra-abdominal pressure (IAP) is an adverse complication seen in
critically ill, injured, and postoperative patients. IAP is estimated via the measurement of …

[HTML][HTML] Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models

…, T Singh, J Klumperman, O Foreman, MC Chang… - Nature aging, 2022 - nature.com
Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By
integrative multi-omics analysis, here we show that astrocytic and microglial proteins are …

Late fascial closure in lieu of ventral hernia: the next step in open abdomen management

…, BJ Faler, JW Meredith, MC Chang - Journal of Trauma …, 2002 - journals.lww.com
Background The use of open abdomen techniques in damage control laparotomy and
abdominal compartment syndrome has led to development of several methods of temporary …