In a large-scale screen, we isolated mutants displaying a specific visible phenotype in
embryos or early larvae of the zebrafish, Danio rerio. Males were mutagenized with …

Background Sepsis-induced multiple organ failure is the major cause of mortality and
morbidity in critically ill patients. However, the precise mechanisms by which this dysfunction is …

Background Myocardial infarction is a frequent cause of out-of-hospital cardiac arrest. However,
the benefits of early coronary angiography and revascularization in resuscitated patients …

Zebrafish embryos and larvae have stage-specific patterns of motility or locomotion. Two
embryonic structures accomplish this behavior: the central nervous system (CNS) and skeletal …

Somitogenesis is the basis of segmentation of the mesoderm in the trunk and tail of
vertebrate embryos. Two groups of mutants with defects in this patterning process have been …

We describe the isolation of zebrafish Fgf8 and its expression during gastrulation,
somitogenesis, fin bud and early brain development. By demonstrating genetic linkage and by …

Neural crest development involves cell-fate specification, proliferation, patterned cell
migration, survival and differentiation. Zebrafish neural crest derivatives include three distinct …

In a screen for early developmental mutants of the zebrafish, we have identified mutations
specifically affecting the internal organs. We identified 53 mutations affecting the …

Lifelong neurogenesis in vertebrates relies on stem cells producing proliferation zones that
contain neuronal precursors with distinct fates. Proliferation zones in the adult zebrafish brain …

Over the past decade, the zebrafish has become an important model organism for biological
research. In recent years, more than 1800 zebrafish mutants have been identified, providing …