Dopamine released by amphetamine decreases the in vivo binding of PET radioligands to
the dopamine D 2 receptor. Although concentrations of extracellular dopamine largely return …

Schizophrenia has long been associated with an imbalance in dopamine (DA) neurotransmission,
and brain imaging has played an important role in advancing our knowledge and …

Synaptic pathology is associated with several brain disorders, thus positron emission tomography
(PET) imaging of synaptic vesicle glycoprotein 2A (SV2A) using the radioligand [ 11 C]…

BACKGROUND: An imaging method to probe glutamate levels in vivo would allow the study
of glutamate transmission in disease states and in response to therapeutic interventions. …

It is well documented that dopamine can increase or decrease the activity of the Na + ,K + -ATPase
(NKA, sodium pump) in an organ-specific fashion. This regulation can occur, at least …

Positron Emission Tomography (PET) has been used for more than three decades to image
and quantify dopamine D 2 receptors (D 2 R) in vivo with antagonist radioligands but in the …

Presynaptic dopamine (DA) transmission has been measured in schizophrenia using different
paradigms aimed at providing estimates of the integrity or the activity of the presynaptic …

Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by
a CAG trinucleotide expansion in the huntingtin (HTT) gene that encodes the pathologic …

Synaptic dysfunction is a primary mechanism underlying Huntington’s Disease (HD) progression.
This study investigated changes in synaptic vesicle glycoprotein 2A (SV2A) density by …

Materials and Methods The D2-like agonist 2-methoxy-N-propylnorapomorphine (MNPA) was
synthesized by Christer Halldin at the Karolinska Institute. MNPA exhibits high affinity (∼ 1 …