Microglia, the brain's resident macrophages, are dynamic CNS custodians with surprising
origins in the extra-embryonic yolk sac. The consequences of their distinct ontogeny are …

BACKGROUND Detecting tumor-derived cell-free DNA (cfDNA) in the blood of brain tumor
patients is challenging, presumably owing to the blood–brain barrier. Cerebral spinal fluid (…

The specific function of microglia, the tissue resident macrophages of the brain and spinal
cord, has been difficult to ascertain because of a lack of tools to distinguish microglia from …

Cerebral spinal fluid (CSF) from brain tumor patients contains tumor cellular and cell-free
DNA (cfDNA), which provides a less-invasive and routinely accessible method to obtain tumor …

The human brain is a tissue of vast complexity in terms of the cell types it comprises. Conventional
approaches to classifying cell types in the human brain at single cell resolution have …

Glioblastoma (GBM) is the most common primary brain cancer in adults and is notoriously
difficult to treat because of its diffuse nature. We performed single-cell RNA sequencing (RNA-…

The Hedgehog (Hh) signaling pathway has been implicated in the most common childhood
brain tumor, medulloblastoma (MB). Given the toxicity of post-surgical treatments for MB, …

The detection of tumor-derived circulating nucleic acids in patients with cancer, known as
the “liquid biopsy,” has expanded from use in plasma to other bodily fluids in an increasing …

Non-small cell lung cancer (NSCLC) metastatic to the brain leptomeninges is rapidly fatal,
cannot be biopsied, and cancer cells in the cerebrospinal fluid (CSF) are few; therefore, …

… Bhambhvani HP, Rodrigues AJ, Yu JS, Carr JB, Hayden Gephart M. Hospital Volumes of
5 Medical Emergencies in the COVID-19 Pandemic in 2 US Medical Centers. JAMA Intern …