The Precision Medicine Initiative aims to use advances in basic and clinical research to
develop therapeutics that selectively target and kill cancer cells. Under the same doctrine of …

Clostridium difficile infection (CDI) is a worldwide health threat that is typically triggered by
the use of broad-spectrum antibiotics, which disrupt the natural gut microbiota and allow this …

Antibiotic resistance is a significant emerging health threat. Exacerbating this problem is the
overprescription of antibiotics as well as a lack of development of new antibacterial agents. …

Serine hydrolases play diverse roles in regulating host–pathogen interactions in a number
of organisms, yet few have been characterized in the human pathogen Staphylococcus …

Fluorescence imaging is currently being actively developed for surgical guidance; however,
it remains underutilized for diagnostic and endoscopic surveillance of incipient colorectal …

Although there have been numerous advances in our understanding of how apicomplexan
parasites such as Toxoplasma gondii enter host cells, many of the signaling pathways and …

Active enzymes, such as proteases, often serve as valuable biomarkers for various disease
pathologies. Therefore, methods to detect specific enzyme activities in biological samples …

Clostridioides difficile infection (CDI) is an enteric bacterial disease that is increasing in
incidence worldwide. Symptoms of CDI range from mild diarrhea to severe life-threatening …

Clostridium difficile infection (CDI) is an enteric bacterial disease that is increasing in
prevalence worldwide. C. difficile capitalizes on gut inflammation and microbiome dysbiosis to …

Macrophages are cellular mediators of vascular inflammation and are involved in the
formation of atherosclerotic plaques. These immune cells secrete proteases such as matrix …