Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-3/7 specific [18F]-labeled isatin sulfonamide
…, G Smith, M Glaser, M Perumal… - Proceedings of the …, 2009 - National Acad Sciences
Of the molecular biochemical alterations that occur during apoptosis, activation of caspases,
notably caspase-3, is probably the most attractive for developing specific in vivo molecular …
notably caspase-3, is probably the most attractive for developing specific in vivo molecular …
Design, Synthesis, and Biological Characterization of a Caspase 3/7 Selective Isatin Labeled with 2-[18F]fluoroethylazide
G Smith, M Glaser, M Perumal… - Journal of medicinal …, 2008 - ACS Publications
Imaging of programmed cell death (apoptosis) is important in the assessment of therapeutic
response in oncology and for diagnosis in cardiac and neurodegenerative disorders. The …
response in oncology and for diagnosis in cardiac and neurodegenerative disorders. The …
Early Detection of Tumor Response to Chemotherapy by 3′-Deoxy-3′-[18F]Fluorothymidine Positron Emission Tomography: The Effect of Cisplatin on a Fibrosarcoma Tumor …
J Leyton, JR Latigo, M Perumal, H Dhaliwal, Q He… - Cancer research, 2005 - AACR
We have assessed the potential of [ 18 F]fluorothymidine positron emission tomography ([
18 F]FLT-PET) to measure early cytostasis and cytotoxicity induced by cisplatin treatment of …
18 F]FLT-PET) to measure early cytostasis and cytotoxicity induced by cisplatin treatment of …
The uptake of 3′-deoxy-3′-[18F]fluorothymidine into L5178Y tumours in vivo is dependent on thymidine kinase 1 protein levels
H Barthel, M Perumal, J Latigo, Q He, F Brady… - European journal of …, 2005 - Springer
Purpose The aim of this study was to investigate the role of thymidine kinase 1 (TK 1 )
protein in 3′-deoxy-3′-[ 18 F]fluorothymidine ([ 18 F]FLT) positron emission tomography (PET) …
protein in 3′-deoxy-3′-[ 18 F]fluorothymidine ([ 18 F]FLT) positron emission tomography (PET) …
Redistribution of nucleoside transporters to the cell membrane provides a novel approach for imaging thymidylate synthase inhibition by positron emission …
Thymidylate synthase (EC 2.1.1.45) is a key enzyme for the de novo synthesis of DNA and
as such a target for anticancer drug development. There is a need to develop noninvasive …
as such a target for anticancer drug development. There is a need to develop noninvasive …
Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity
F Chan, C Sun, M Perumal, QD Nguyen… - Molecular cancer …, 2007 - AACR
The Aurora family of serine/threonine kinases is important for the regulation of centrosome
maturation, chromosome segregation, and cytokinesis during mitosis. Overexpression of …
maturation, chromosome segregation, and cytokinesis during mitosis. Overexpression of …
Targeting somatostatin receptors: preclinical evaluation of novel 18F-fluoroethyltriazole-Tyr3-octreotate analogs for PET
J Leyton, L Iddon, M Perumal, B Indrevoll… - Journal of nuclear …, 2011 - Soc Nuclear Med
The incidence and prevalence of gastroenteropancreatic neuroendocrine tumors has been
increasing over the past 3 decades. Because of high densities of somatostatin receptors (sstr)…
increasing over the past 3 decades. Because of high densities of somatostatin receptors (sstr)…
Radiosynthesis and pre-clinical evaluation of [18F] fluoro-[1, 2-2H4] choline
G Smith, Y Zhao, J Leyton, B Shan, M Perumal… - Nuclear medicine and …, 2011 - Elsevier
INTRODUCTION: Choline radiotracers are widely used for clinical PET diagnosis in oncology.
[ 11 C]Choline finds particular utility in the imaging of brain and prostate tumor metabolic …
[ 11 C]Choline finds particular utility in the imaging of brain and prostate tumor metabolic …
In vivo Biological Activity of the Histone Deacetylase Inhibitor LAQ824 Is detectable with 3′-Deoxy-3′-[18F]Fluorothymidine Positron Emission Tomography
…, M Da Costa, AV Stavropoulou, JR Latigo, M Perumal… - Cancer Research, 2006 - AACR
Histone deacetylase inhibitors (HDACI) are emerging as growth inhibitory compounds that
modulate gene expression and inhibit tumor cell proliferation. We assessed whether 3′-…
modulate gene expression and inhibit tumor cell proliferation. We assessed whether 3′-…
Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901
J Leyton, G Smith, M Lees, M Perumal, Q Nguyen… - Molecular Cancer …, 2008 - AACR
The mitogenic extracellular kinase 1/2 (MEK1/2) inhibitor, PD0325901, has potent activity in
a number of cancer cell types in vitro. In SKMEL-28 human melanoma cells (BRAF mutant), …
a number of cancer cell types in vitro. In SKMEL-28 human melanoma cells (BRAF mutant), …