Radiation damage to the lung: Mitigation by angiotensin‐converting enzyme (ACE) inhibitors
M Medhora, F Gao, ER Jacobs, JE Moulder - Respirology, 2012 - Wiley Online Library
Concern regarding accidental overexposure to radiation has been raised after the devastating
Tohuku earthquake and tsunami which initiated the Fukushima Daiichi nuclear disaster in …
Tohuku earthquake and tsunami which initiated the Fukushima Daiichi nuclear disaster in …
Animal models for medical countermeasures to radiation exposure
…, TJ MacVittie, KA Mason, MM Medhora… - Radiation …, 2010 - meridian.allenpress.com
Since September 11, 2001, there has been the recognition of a plausible threat from acts of
terrorism, including radiological or nuclear attacks. A network of Centers for Medical …
terrorism, including radiological or nuclear attacks. A network of Centers for Medical …
Molecular structure of a somatically unstable transposable element in Drosophila.
JW Jacobson, MM Medhora… - Proceedings of the …, 1986 - National Acad Sciences
A transposable element has been isolated from an unstable white mutation in Drosophila
mauritiana, a sibling species of Drosophila melanogaster. The unstable white-peach (wpch) …
mauritiana, a sibling species of Drosophila melanogaster. The unstable white-peach (wpch) …
Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia
…, PK Patel, ER Jacobs, M Medhora - American Journal …, 2008 - journals.physiology.org
Epoxyeicosatrienoic acids (EETs) reduce infarction of the myocardium after ischemia-reperfusion
injury to rodent and dog hearts mainly by opening sarcolemmal and mitochondrial …
injury to rodent and dog hearts mainly by opening sarcolemmal and mitochondrial …
Salen Mn complexes mitigate radiation injury in normal tissues
…, Z Lazarova, J Mahmood, M Medhora… - Anti-Cancer Agents …, 2011 - ingentaconnect.com
Salen Mn complexes, including EUK-134, EUK-189 and a newer cyclized analog EUK-207,
are synthetic SOD/catalase mimetics that have beneficial effects in many models of oxidative …
are synthetic SOD/catalase mimetics that have beneficial effects in many models of oxidative …
Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes
NJ Alkayed, J Narayanan, D Gebremedhin, M Medhora… - Stroke, 1996 - Am Heart Assoc
Background and Purpose Brain parenchymal tissue metabolizes arachidonic acid (AA) via
the cytochrome P450 (P450) epoxygenase to epoxyeicosatrienoic acids (EETs). EETs dilate …
the cytochrome P450 (P450) epoxygenase to epoxyeicosatrienoic acids (EETs). EETs dilate …
Cytochrome P450 2C9‐derived epoxyeicosatrienoic acids induce angiogenesis via cross‐talk with the epidermal growth factor receptor
UR Michaelis, B Fisslthaler, M Medhora… - The FASEB …, 2003 - Wiley Online Library
Cytochrome P450 (CYP) epoxygenase products, such as 11,12‐epoxyeicosatrienoic acid (EET),
stimulate endothelial cell proliferation. We set out to identify the signal transduction …
stimulate endothelial cell proliferation. We set out to identify the signal transduction …
Near infrared light protects cardiomyocytes from hypoxia and reoxygenation injury by a nitric oxide dependent mechanism
…, HT Whelan, D Zhu, ER Jacobs, M Medhora… - Journal of molecular and …, 2009 - Elsevier
Photobiomodulation with near infrared light (NIR) provides cellular protection in various
disease models. Previously, infrared light emitted by a low-energy laser has been shown to …
disease models. Previously, infrared light emitted by a low-energy laser has been shown to …
Chronic hypoxia activates lung 15-lipoxygenase, which catalyzes production of 15-HETE and enhances constriction in neonatal rabbit pulmonary arteries
D Zhu, M Medhora, WB Campbell, N Spitzbarth… - Circulation …, 2003 - Am Heart Assoc
Hypoxia causes localized pulmonary arterial (PA) constriction to divert blood flow to optimally
ventilated regions of the lung. The biochemical mechanisms for this have remained elusive…
ventilated regions of the lung. The biochemical mechanisms for this have remained elusive…
Renin-Angiotensin system suppression mitigates experimental radiation pneumonitis
…, XA Li, JE Moulder, ER Jacobs, M Medhora - International Journal of …, 2009 - Elsevier
PURPOSE: To find the mitigators of pneumonitis induced by moderate doses of thoracic
radiation (10–15 Gy). METHODS AND MATERIALS: Unanesthetized WAG/RijCmcr female rats …
radiation (10–15 Gy). METHODS AND MATERIALS: Unanesthetized WAG/RijCmcr female rats …