Radiation damage to the lung: Mitigation by angiotensin‐converting enzyme (ACE) inhibitors

M Medhora, F Gao, ER Jacobs, JE Moulder - Respirology, 2012 - Wiley Online Library
Concern regarding accidental overexposure to radiation has been raised after the devastating
Tohuku earthquake and tsunami which initiated the Fukushima Daiichi nuclear disaster in …

Animal models for medical countermeasures to radiation exposure

…, TJ MacVittie, KA Mason, MM Medhora… - Radiation …, 2010 - meridian.allenpress.com
Since September 11, 2001, there has been the recognition of a plausible threat from acts of
terrorism, including radiological or nuclear attacks. A network of Centers for Medical …

Molecular structure of a somatically unstable transposable element in Drosophila.

JW Jacobson, MM Medhora… - Proceedings of the …, 1986 - National Acad Sciences
A transposable element has been isolated from an unstable white mutation in Drosophila
mauritiana, a sibling species of Drosophila melanogaster. The unstable white-peach (wpch) …

Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia

…, PK Patel, ER Jacobs, M Medhora - American Journal …, 2008 - journals.physiology.org
Epoxyeicosatrienoic acids (EETs) reduce infarction of the myocardium after ischemia-reperfusion
injury to rodent and dog hearts mainly by opening sarcolemmal and mitochondrial …

Salen Mn complexes mitigate radiation injury in normal tissues

…, Z Lazarova, J Mahmood, M Medhora… - Anti-Cancer Agents …, 2011 - ingentaconnect.com
Salen Mn complexes, including EUK-134, EUK-189 and a newer cyclized analog EUK-207,
are synthetic SOD/catalase mimetics that have beneficial effects in many models of oxidative …

Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes

NJ Alkayed, J Narayanan, D Gebremedhin, M Medhora… - Stroke, 1996 - Am Heart Assoc
Background and Purpose Brain parenchymal tissue metabolizes arachidonic acid (AA) via
the cytochrome P450 (P450) epoxygenase to epoxyeicosatrienoic acids (EETs). EETs dilate …

Cytochrome P450 2C9‐derived epoxyeicosatrienoic acids induce angiogenesis via cross‐talk with the epidermal growth factor receptor

UR Michaelis, B Fisslthaler, M Medhora… - The FASEB …, 2003 - Wiley Online Library
Cytochrome P450 (CYP) epoxygenase products, such as 11,12‐epoxyeicosatrienoic acid (EET),
stimulate endothelial cell proliferation. We set out to identify the signal transduction …

Near infrared light protects cardiomyocytes from hypoxia and reoxygenation injury by a nitric oxide dependent mechanism

…, HT Whelan, D Zhu, ER Jacobs, M Medhora… - Journal of molecular and …, 2009 - Elsevier
Photobiomodulation with near infrared light (NIR) provides cellular protection in various
disease models. Previously, infrared light emitted by a low-energy laser has been shown to …

Chronic hypoxia activates lung 15-lipoxygenase, which catalyzes production of 15-HETE and enhances constriction in neonatal rabbit pulmonary arteries

D Zhu, M Medhora, WB Campbell, N Spitzbarth… - Circulation …, 2003 - Am Heart Assoc
Hypoxia causes localized pulmonary arterial (PA) constriction to divert blood flow to optimally
ventilated regions of the lung. The biochemical mechanisms for this have remained elusive…

Renin-Angiotensin system suppression mitigates experimental radiation pneumonitis

…, XA Li, JE Moulder, ER Jacobs, M Medhora - International Journal of …, 2009 - Elsevier
PURPOSE: To find the mitigators of pneumonitis induced by moderate doses of thoracic
radiation (10–15 Gy). METHODS AND MATERIALS: Unanesthetized WAG/RijCmcr female rats …