Comparison of somatostatin receptor 2-targeting PET tracers in the detection of mouse atherosclerotic plaques

…, S Hellberg, M Kiugel, J Virta, XG Li, M Käkelä… - Molecular Imaging and …, 2016 - Springer
Purpose Rupture-prone atherosclerotic plaques are characterized by accumulation of
macrophages, which have shown to express somatostatin type 2 receptors. We aimed to …

[HTML][HTML] Absorption, distribution and excretion of intravenously injected 68Ge/68Ga generator eluate in healthy rats, and estimation of human radiation dosimetry

…, V Oikonen, T Saanijoki, R Siitonen, M Käkelä… - EJNMMI research, 2015 - Springer
Background This study evaluated the absorption, distribution, and excretion of Gallium-68 (
68 Ga) radionuclide after a single intravenous (iv) injection of 68 Ge/ 68 Ga generator eluate …

[HTML][HTML] 68Ga-DOTA-Siglec-9 – a new imaging tool to detect synovitis

…, T Saanijoki, P Lankinen, J Mäkilä, M Käkelä… - Arthritis Research & …, 2015 - Springer
Introduction Vascular adhesion protein-1 (VAP-1) is an adhesion molecule, which upon
inflammation is rapidly translocated from intracellular sources to the endothelial cell surface. We …

[HTML][HTML] Leukocyte trafficking-associated vascular adhesion protein 1 is expressed and functionally active in atherosclerotic plaques

…, O Metsälä, M Ståhle, T Saanijoki, M Käkelä… - Scientific reports, 2016 - nature.com
Given the important role of inflammation and the potential association of the leukocyte
trafficking-associated adhesion molecule vascular adhesion protein 1 (VAP-1) with atherosclerosis…

[HTML][HTML] Imaging of αvβ3 integrin expression in experimental myocardial ischemia with [68Ga]NODAGA-RGD positron emission tomography

…, T Savunen, T Tolvanen, J Teuho, M Käkelä… - Journal of Translational …, 2017 - Springer
Background Radiolabeled RGD peptides detect α v β 3 integrin expression associated with
angiogenesis and extracellular matrix remodeling after myocardial infarction. We studied …

[HTML][HTML] Radiosynthesis and preclinical evaluation of [68Ga]Ga-NOTA-folate for PET imaging of folate receptor β-positive macrophages

…, J Virta, P Elo, H Liljenbäck, T Tolvanen, M Käkelä… - Scientific Reports, 2020 - nature.com
Folate receptor β (FR-β), a marker expressed on macrophages, is a promising target for imaging
of inflammation. Here, we report the radiosynthesis and preclinical evaluation of [ 68 Ga]…

[HTML][HTML] Evaluation of [68Ga]Ga-DOTA-TCTP-1 for the Detection of Metalloproteinase 2/9 Expression in Mouse Atherosclerotic Plaques

M Kiugel, S Hellberg, M Käkelä, H Liljenbäck… - Molecules, 2018 - mdpi.com
Background: The expression of matrix metalloproteinases 2/9 (MMP-2/9) has been implicated
in arterial remodeling and inflammation in atherosclerosis. We evaluated a gallium-68 …

[HTML][HTML] Value of 68Ga-labeled bombesin antagonist (RM2) in the detection of primary prostate cancer comparing with [18F]fluoromethylcholine PET-CT and …

…, I Jambor, A Müller, W Loidl, E Kähkönen, M Käkelä… - European …, 2023 - Springer
Objectives The bombesin derivative RM2 is a GRPr antagonist with strong binding affinity to
prostate cancer (PCa). In this study, the impact of [ 68 Ga]Ga-RM2 positron emission …

68Ga-DOTA-E [c (RGDfK)] 2 PET imaging of SHARPIN-regulated integrin activity in mice

…, E Mattila, O Metsälä, M Käkelä… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Shank-associated RH domain-interacting protein (SHARPIN) is a cytosolic protein that
plays a key role in activation of nuclear factor κ-light-chain enhancer of activated B cells and …

Synthesis of multi-galactose-conjugated 2′-O-methyl oligoribonucleotides and their in vivo imaging with positron emission tomography

J Mäkilä, S Jadhav, A Kiviniemi, M Käkelä… - Bioorganic & medicinal …, 2014 - Elsevier
68 Ga labelled 2′-O-methyl oligoribonucleotides (anti-miR-15b) bearing one, three or seven
d-galactopyranoside residues have been prepared and their distribution in healthy rats …