Importance There is tremendous interest in using immunotherapy to treat breast cancer, as
evidenced by the more than 290 clinical trials ongoing at the time of this narrative review. The …

The abscopal effect refers to the ability of localized radiation to trigger systemic antitumor
effects. Over the past 50 years, reports on the abscopal effect arising from conventional …

Historically, breast cancer tumors have been considered immunologically quiescent, with
the majority of tumors demonstrating low lymphocyte infiltration, low mutational burden, and …

Background The addition of pembrolizumab to neoadjuvant chemotherapy led to a
significantly higher percentage of patients with early triple-negative breast cancer having a …

Background Previous trials showed promising antitumor activity and an acceptable safety
profile associated with pembrolizumab in patients with early triple-negative breast cancer. …

Purpose: To assess the safety and tolerability of preoperative cryoablation-mediated tumor
antigen presentation and/or ipilimumab-mediated immune modulation in women with …

Our objective was to determine whether imaging with a human epidermal growth factor
receptor 2 (HER2)–targeted PET tracer can detect HER2-positive metastases in patients with …

Background The current study was conducted to evaluate the efficacy and safety of
pembrolizumab‐mediated programmed cell death protein 1 inhibition plus radiotherapy (RT) in …

Immune checkpoint inhibitor therapies targeting PD‐1/PD‐L1 are now the standard of care
in oncology across several hematologic and solid tumor types, including triple negative …

Purpose: There are no validated methods of early detection of cardiotoxicity from trastuzumab
(T) following anthracycline-based chemotherapy. Currently changes in left ventricular …