Conjugation of antibodies with bifunctional chelating agents: isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of metal …
…, DA Goodwin, CI Diamanti, M McTigue - Analytical …, 1984 - Elsevier
Preparation of the chelating agent (S)-4-[2,3-bis[bis(carboxymethyl)amino]propyl]phenyl
isothiocyanate is reported. Procedures for conjugation of this and (S)-N-4-[2,3-bis[bis(…
isothiocyanate is reported. Procedures for conjugation of this and (S)-N-4-[2,3-bis[bis(…
Antibodies against metal chelates
DT Reardan, CF Meares, DA Goodwin, M McTigue… - Nature, 1985 - nature.com
Because monoclonal antibodies can recognize and bind to specific groups of atoms such
as tumour antigens, they have promise for use in vivo as carriers of radionuclides, drugs or …
as tumour antigens, they have promise for use in vivo as carriers of radionuclides, drugs or …
[PDF][PDF] Pre-targeted immunoscintigraphy of murine tumors with indium-111-labeled bifunctional haptens
…, CF Meares, MJ McCall, M McTigue… - Journal of nuclear …, 1988 - Soc Nuclear Med
A method of tumor imaging utilizingthe nonspecific accumulation of antibody through leaky
capillaries is described, in which the antibody and the radiolabel are administered separately…
capillaries is described, in which the antibody and the radiolabel are administered separately…
Pharmacokinetics of Pretargeted Monoclonal Antibody 2D12.5 and 88Y-Janus-2-(p-Nitrobenzyl)-1,4,7,10-tetraazacyclododecanetetraacetic Acid (DOTA) in BALB/c Mice with …
DA Goodwin, CF Meares, N Watanabe, M McTigue… - Cancer research, 1994 - AACR
Three-step pretargeting for radioimmunotherapy in BALB/c mice with KHJJ tumors was
done with monoclonal antibody (mAb) 2D12.5, which is specific for yttrium-1,4,7,10-…
done with monoclonal antibody (mAb) 2D12.5, which is specific for yttrium-1,4,7,10-…
Use of specific antibody for rapid clearance of circulating blood background from radiolabeled tumor imaging proteins
…, M McCall, C Lai, F Torti, M McTigue… - European journal of …, 1984 - Springer
A major problem that arises when radiolabeled serum proteins are used for tumor imaging
is the presence of a large amount of circulating background activity that persists for several …
is the presence of a large amount of circulating background activity that persists for several …
[PDF][PDF] Pretargeted immunoscintigraphy: effect of hapten valency on murine tumor uptake
DA Goodwin, CF Meares, M McTigue… - Journal of Nuclear …, 1992 - Soc Nuclear Med
(S)-lp-aminobenzyl-EDTA, prepared as described earlier (9, 11), was added to 18 ml of H20,
the pH adjusted to 7.4 using 3 M NaOH and then 489 zlof neat diisopropylethylamine added…
the pH adjusted to 7.4 using 3 M NaOH and then 489 zlof neat diisopropylethylamine added…
Renal and systemic acid-base effects of the chronic administration of hypercalcemia-producing agents: calcitriol, PTH, and intravenous calcium
…, RD Toto, EL Bonner Jr, LP Ilnicki, M McTigue - Kidney international, 1982 - Elsevier
Renal and systemic acid-base effects of the chronic administration of hypercalcemia-producing
agents: Calcitriol, PTH, and intravenous calcium. Balance studies were performed in …
agents: Calcitriol, PTH, and intravenous calcium. Balance studies were performed in …
[PDF][PDF] Chelate conjugates of monoclonal antibodies for imaging lymphoid structures in the mouse
…, MJ McCall, MK Haseman, M McTigue… - Journal of nuclear …, 1985 - Soc Nuclear Med
Radiolabeling of a mouse monoclonal antibody (MoAb) specific for the mouse histocompatibility
alloantigen IAk expressed by the B lymphocytes of BALB/k and C3H mice but not BALB/…
alloantigen IAk expressed by the B lymphocytes of BALB/k and C3H mice but not BALB/…
Immunogenicity in Rabbits and Mice of an Antibody-Chelate Conjugate: Comparison of (S) and (R) Macrocyclic Enantiomers and an Acyclic Chelating Agent
N Watanabe, DA Goodwin, CF Meares, M McTigue… - Cancer research, 1994 - AACR
The macrocyclic bifunctional chelating agent 2-(p-bromoacetamido-benzyl)-1,4,7,10-tetraazacycIododecanetetraacetic
acid (BAD), forms inert metal complexes ideal for …
acid (BAD), forms inert metal complexes ideal for …
Rapid synthesis and quality control of 68Ga-labeled chelates for clinical use
…, CMK Ransone, CI Diamanti, M McTigue - Nuclear medicine and …, 1994 - Elsevier
Rapid synthesis of radiopharmaceuticals labeled with 68 Ga obtained from a 68 Ge 68 Ga
generator is described. Approximately 70% of the available 68 Ga activity was obtained in 4 …
generator is described. Approximately 70% of the available 68 Ga activity was obtained in 4 …