Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer

…, A Maria Orengo, S Capitanio, L Emionite, M Riondato… - Cell cycle, 2013 - Taylor & Francis
Emerging evidence suggests that metformin, a widely used anti-diabetic drug, may be useful
in the prevention and treatment of different cancers. In the present study, we demonstrate …

18F-NaF uptake by atherosclerotic plaque on PET/CT imaging: inverse correlation between calcification density and mineral metabolic activity

…, M Cabria, A Democrito, M Riondato… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Several studies have highlighted the role of vascular 18 F-NaF uptake as a marker of
ongoing calcium deposition. However, accumulation of 18 F-NaF is often inconsistent with …

Oldie but goodie: Is technetium-99m still a treasure trove of innovation for medicine? A Patents Analysis (2000–2022)

M Riondato, D Rigamonti, P Martini… - Journal of Medicinal …, 2023 - ACS Publications
Technetium-99m is the workhorse of diagnostic nuclear medicine. The aim of the work is to
analyze the technetium-99m patents since 2000 to photograph its innovation. QUESTEL’s …

Toward the discovery and development of PSMA targeted inhibitors for nuclear medicine applications

S Pastorino, M Riondato, L Uccelli… - Current …, 2020 - ingentaconnect.com
Background: The rising incidence rate of prostate cancer (PCa) has promoted the
development of new diagnostic and therapeutic radiopharmaceuticals during the last decades. …

Metformin temporal and localized effects on gut glucose metabolism assessed using 18F-FDG PET in mice

…, L Emionite, B Salani, M Riondato… - Journal of Nuclear …, 2013 - Soc Nuclear Med
In the course of metformin treatment, staging abdominal cancer lesions with 18 F-FDG PET
images is often hindered by the presence of a high bowel radioactivity. The present study …

PET and PET/CT with radiolabeled choline in prostate cancer: a critical reappraisal of 20 years of clinical studies

…, E Giovannini, R Leoncini, M Riondato… - European Journal of …, 2017 - Springer
We here aim to provide a comprehensive and critical review of the literature concerning the
clinical applications of positron emission tomography/computed tomography (PET/CT) with …

[HTML][HTML] Combined forced diuresis and late acquisition on [68Ga]Ga-PSMA-11 PET/CT for biochemical recurrent prostate cancer: a clinical practice-oriented study

…, R Laudicella, A Franchini, F D'Amico, M Riondato… - European …, 2023 - Springer
Objectives Increased detection of prostate cancer (PCa) recurrences using [ 68 Ga]Ga-PSMA-11
PET/CT has been reported by adding forced diuresis or late-phase imaging to the …

[HTML][HTML] Fundamental role of pentose phosphate pathway within the endoplasmic reticulum in glutamine addiction of triple-negative breast cancer cells

…, S Bruno, F Vitale, M Bonanomi, D Porro, M Riondato… - Antioxidants, 2022 - mdpi.com
Cancer utilization of large glutamine equivalents contributes to diverging glucose-6-P flux
toward the pentose phosphate shunt (PPP) to feed the building blocks and the antioxidant …

PET/CT With 68Ga-PSMA in prostate cancer: radiopharmaceutical background and clinical implications

…, E Giovannini, M Riondato… - Current …, 2018 - ingentaconnect.com
Background and objective: In the last twenty years, positron emission tomography / computed
tomography (PET/CT) with radiolabeled choline, represented the most powerful imaging …

Direct relationship between cell density and FDG uptake in asymptomatic aortic aneurysm close to surgical threshold: an in vivo and in vitro study

…, R Armonino, G Spinella, M Riondato… - European journal of …, 2012 - Springer
Purpose Conflicting results have been reported about the clinical value of fluorodeoxyglucose
(FDG) imaging in predicting the risk of rupture of abdominal aortic aneurysm (AAA). The …