Purpose: To provide proof of principle of safety, breast tumor–specific uptake, and positive
tumor margin assessment of the systemically administered near-infrared fluorescent tracer …

Background Optimum cytoreductive surgery combined with hyperthermic intraperitoneal
chemotherapy (HIPEC) is essential for the curative treatment of peritoneal carcinomatosis of …

Inadequate surgical margins occur frequently in oral squamous cell carcinoma surgery.
Fluorescence molecular imaging (FMI) has been explored for intraoperative margin assessment, …

During the last decade, the emerging field of molecular fluorescence imaging has led to the
development of tumor-specific fluorescent tracers and an increase in early-phase clinical …

The incidence of oesophageal adenocarcinoma (EAC) is steeply rising. Early lesion detection
is a critical factor for improving disease prognosis. We developed and investigated wide-…

There is a dire need for better visualization of cancer and analysis of specific targets in vivo.
Molecular imaging with fluorescence is gaining more and more attention, as it allows …

Resection of soft-tissue sarcoma (STS) is accompanied by a high rate of tumor-positive
surgical margins (14%–34%), which potentially lead to decreased disease-free survival. …

Adenoma miss rates in colonoscopy are unacceptably high, especially for sessile serrated
adenomas/polyps (SSA/Ps) and in high-risk populations, such as patients with Lynch …

Negative circumferential resection margins (CRM) are the cornerstone for the curative
treatment of locally advanced rectal cancer (LARC). However, in up to 18.6% of patients, tumor-…

Quantitative fluorescence endoscopy (QFE) is a new technique that can visualise and quantify
fluorescently tagged tumour tissue. In 25 patients with locally advanced rectal cancer (…