Analysis of shared heritability in common disorders of the brain
…, PL De Jager, DH Geschwind, M Riemenschneider… - Science, 2018 - science.org
INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …
Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study
…, H Siebner, M Riemenschneider… - European journal of …, 2003 - Springer
A high percentage of patients with mild cognitive impairment (MCI) develop clinical dementia
of the Alzheimer type (AD) within 1 year. The aim of this longitudinal study was to identify …
of the Alzheimer type (AD) within 1 year. The aim of this longitudinal study was to identify …
Frontotemporal dementia and its subtypes: a genome-wide association study
…, JE Nielsen, LE Hjermind, M Riemenschneider… - The Lancet …, 2014 - thelancet.com
Background Frontotemporal dementia (FTD) is a complex disorder characterised by a broad
range of clinical manifestations, differential pathological signatures, and genetic variability. …
range of clinical manifestations, differential pathological signatures, and genetic variability. …
Prediction of individual clinical outcome in MCI by means of genetic assessment and 18F-FDG PET
…, T Grimmer, M Riemenschneider… - Journal of Nuclear …, 2005 - Soc Nuclear Med
Patients with mild cognitive impairment (MCI) represent a risk population for progressing to
dementia of the Alzheimer type (DAT). However, clinical criteria do not ensure reliable …
dementia of the Alzheimer type (DAT). However, clinical criteria do not ensure reliable …
Beta amyloid in Alzheimer's disease: increased deposition in brain is reflected in reduced concentration in cerebrospinal fluid
T Grimmer, M Riemenschneider, H Förstl… - Biological …, 2009 - Elsevier
BACKGROUND: A decreased concentration of beta amyloid (1-42) (Aβ42) has consistently
been found in the cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD) and is …
been found in the cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD) and is …
Cerebrospinal fluid tau and β-amyloid 42 proteins identify Alzheimer disease in subjects with mild cognitive impairment
M Riemenschneider, N Lautenschlager… - Archives of …, 2002 - jamanetwork.com
Context Cerebrospinal fluid tau protein and β-amyloid 42 (Aβ42) protein are altered even in
very mild Alzheimer disease (AD). So far, few data exist for subjects with mild cognitive …
very mild Alzheimer disease (AD). So far, few data exist for subjects with mild cognitive …
[HTML][HTML] 24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial
…, K Fassbender, M Riemenschneider… - The Lancet …, 2017 - thelancet.com
Background Nutrition is an important modifiable risk factor in Alzheimer's disease. Previous
trials of the multinutrient Fortasyn Connect showed benefits in mild Alzheimer's disease …
trials of the multinutrient Fortasyn Connect showed benefits in mild Alzheimer's disease …
Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers
…, A Moghekar, R O'Brien, M Riemenschneider… - Acta …, 2017 - Springer
More than 20 genetic loci have been associated with risk for Alzheimer’s disease (AD), but
reported genome-wide significant loci do not account for all the estimated heritability and …
reported genome-wide significant loci do not account for all the estimated heritability and …
Meta-analysis of the association between variants in SORL1 and Alzheimer disease
…, JA Prince, W Maier, M Riemenschneider… - Archives of …, 2011 - jamanetwork.com
Objective To reexamine the association between the neuronal sortilin-related receptor gene
(SORL1) and Alzheimer disease (AD). Design Comprehensive and unbiased meta-analysis …
(SORL1) and Alzheimer disease (AD). Design Comprehensive and unbiased meta-analysis …
[HTML][HTML] DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex
…, T Arzberger, S Roeber, M Riemenschneider… - Epigenetics & …, 2018 - Springer
Background Epigenome-wide association studies (EWAS) based on human brain samples
allow a deep and direct understanding of epigenetic dysregulation in Alzheimer’s disease (…
allow a deep and direct understanding of epigenetic dysregulation in Alzheimer’s disease (…