Imaging of amyloid β in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism
…, T Dyrks, G Holl, S Krause, M Friebe… - The Lancet …, 2008 - thelancet.com
Background Amyloid-β (Aβ) plaque formation is a hallmark of Alzheimer's disease (AD) and
precedes the onset of dementia. Aβ imaging should allow earlier diagnosis, but clinical …
precedes the onset of dementia. Aβ imaging should allow earlier diagnosis, but clinical …
Application of locked nucleic acids to improve aptamer in vivo stability and targeting function
…, AW Stephens, R Bald, M Hecht, M Friebe… - Nucleic acids …, 2004 - academic.oup.com
Aptamers are powerful candidates for molecular imaging applications due to a number of
attractive features, including rapid blood clearance and tumor penetration. We carried out …
attractive features, including rapid blood clearance and tumor penetration. We carried out …
Synthesis, 18F-Labeling, and in Vitro and in Vivo Studies of Bombesin Peptides Modified with Silicon-Based Building Blocks
…, U Klar, U Voigtmann, JE Cyr, M Friebe… - Bioconjugate …, 2008 - ACS Publications
The gastrin-releasing peptide receptor (GRPr) is overexpressed on various human tumors.
The goal of our study was the synthesis of new 18 F-labeled bombesin analogues for the PET …
The goal of our study was the synthesis of new 18 F-labeled bombesin analogues for the PET …
Specific PET Imaging of xC− Transporter Activity Using a 18F-Labeled Glutamate Derivative Reveals a Dominant Pathway in Tumor Metabolism
…, L Toschi, AW Stephens, V Gekeler, M Friebe… - Clinical Cancer …, 2011 - AACR
Purpose: 18 F-labeled small molecules targeting adaptations of tumor metabolism possess
the potential for early tumor detection with high sensitivity and specificity by positron …
the potential for early tumor detection with high sensitivity and specificity by positron …
Dosimetry and first clinical evaluation of the new 18F-radiolabeled bombesin analogue BAY 864367 in patients with prostate cancer
The aim of this first-in-man study was to demonstrate the feasibility, safety, and tolerability,
as well as provide dosimetric data and evaluate the imaging properties, of the bombesin …
as well as provide dosimetric data and evaluate the imaging properties, of the bombesin …
Radioimmunotherapy of solid tumors by targeting extra domain B fibronectin: identification of the best-suited radioimmunoconjugate
…, S Borkowski, S Sieger, A Rother, M Friebe… - Clinical cancer …, 2005 - AACR
Purpose: The expression of extra domain B (ED-B) fibronectin is always associated with
angiogenic processes and can be exclusively observed in tissues undergoing growth and/or …
angiogenic processes and can be exclusively observed in tissues undergoing growth and/or …
[HTML][HTML] Pilot preclinical and clinical evaluation of (4S)-4-(3-[18F] Fluoropropyl)-L-Glutamate (18F-FSPG) for PET/CT imaging of intracranial malignancies
…, AH Iagaru, A Mueller, M Berndt, S Bullich, M Friebe… - PLoS …, 2016 - journals.plos.org
Purpose (S)-4-(3-[ 18 F]Fluoropropyl)-L-glutamic acid (18F-FSPG) is a novel radiopharmaceutical
for Positron Emission Tomography (PET) imaging. It is a glutamate analogue that can …
for Positron Emission Tomography (PET) imaging. It is a glutamate analogue that can …
Imaging of tumor angiogenesis using 99mTc-labeled human recombinant anti-ED-B fibronectin antibody fragments
…, B Müller-Tiemann, S Sieger, M Friebe… - Journal of nuclear …, 2006 - Soc Nuclear Med
The aim of this study was to target the angiogenesis-associated extracellular matrix protein
ED-B fibronectin for molecular imaging of solid tumors. Recombinant and chemically …
ED-B fibronectin for molecular imaging of solid tumors. Recombinant and chemically …
18F-GP1, a novel PET tracer designed for high-sensitivity, low-background detection of thrombi
…, N Koglin, F Oden, M Bauser, M Friebe… - Journal of Nuclear …, 2017 - Soc Nuclear Med
Thromboembolic diseases such as myocardial infarction, stroke, transient ischemic attacks,
and pulmonary embolism are major causes of morbidity and mortality worldwide. …
and pulmonary embolism are major causes of morbidity and mortality worldwide. …
Radiopharmaceutical therapy of patients with metastasized melanoma with the melanin-binding benzamide 131I-BA52
…, FL Giesel, B Beijer, JW Babich, M Friebe… - Journal of Nuclear …, 2014 - Soc Nuclear Med
The performance of cytotoxic drugs is defined by their selectivity of uptake and action in
tumor tissue. Recent clinical responses achieved by treating metastatic malignant melanoma …
tumor tissue. Recent clinical responses achieved by treating metastatic malignant melanoma …