User profiles for Mathieu L. Lepage

Mathieu L. Lepage

CNRS | Univ. Toulouse III - Paul Sabatier
Verified email at cnrs.fr
Cited by 779

A broadly applicable cross-linker for aliphatic polymers containing C–H bonds

ML Lepage, C Simhadri, C Liu, M Takaffoli, L Bi… - Science, 2019 - science.org
Addition of molecular cross-links to polymers increases mechanical strength and improves
corrosion resistance. However, it remains challenging to install cross-links in low-functionality …

Recent advances in 18F radiochemistry: a focus on B-18F, Si-18F, Al-18F, and C-18F radiofluorination via spirocyclic iodonium ylides

V Bernard-Gauthier, ML Lepage… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Straightforward radiosynthesis protocols for 18 F-labeled radiopharmaceuticals are an
indispensable but often overlooked prerequisite to successfully perform molecular imaging …

Direct access to MIDA acylboronates through mild oxidation of MIDA vinylboronates

ML Lepage, S Lai, N Peressin… - Angewandte Chemie …, 2017 - Wiley Online Library
Acylboronate esters/trifluoroborates represent an elusive class of boronates that are of
increasing interest for both fundamental study as well as applications at the interface of chemistry …

Iminosugar‐Cyclopeptoid Conjugates Raise Multivalent Effect in Glycosidase Inhibition at Unprecedented High Levels

ML Lepage, JP Schneider, A Bodlenner… - … A European Journal, 2016 - Wiley Online Library
A series of cyclopeptoid‐based iminosugar clusters has been evaluated to finely probe the
ligand content‐dependent increase in α‐mannosidase inhibition. This study led to the largest …

Structural Basis of Outstanding Multivalent Effects in Jack Bean α‐Mannosidase Inhibition

E Howard, A Cousido‐Siah, ML Lepage… - Angewandte Chemie …, 2018 - Wiley Online Library
Multivalent design of glycosidase inhibitors is a promising strategy for the treatment of
diseases involving enzymatic hydrolysis of glycosidic bonds in carbohydrates. An essential …

[HTML][HTML] Flexible polyfluorinated bis-diazirines as molecular adhesives

C Simhadri, L Bi, ML Lepage, M Takaffoli, Z Pei… - Chemical …, 2021 - pubs.rsc.org
Motivated by a desire to develop flexible covalent adhesives that afford some of the same
malleability in the adhesive layer as traditional polymer-based adhesives, we designed and …

[HTML][HTML] A sustainable polymer and coating system based on renewable raw materials

JGH Hermens, T Freese, G Alachouzos, ML Lepage… - Green …, 2022 - pubs.rsc.org
Paints and coatings are widely used in modern society and their current production is
mainly dependent on the petrochemical industry. The establishment of processes using …

Giant Glycosidase Inhibitors: First‐and Second‐Generation Fullerodendrimers with a Dense Iminosugar Shell

…, A Joosten, M Holler, ML Lepage… - … A European Journal, 2018 - Wiley Online Library
The multivalent effect in glycosidase inhibition is a new topic in glycoscience that has
emerged a few years ago, with the discovery of neoglycoclusters displaying strong binding …

[HTML][HTML] Synthesis of the first examples of iminosugar clusters based on cyclopeptoid cores

ML Lepage, A Meli, A Bodlenner… - Beilstein journal of …, 2014 - beilstein-journals.org
Cyclic N-propargyl α-peptoids of various sizes were prepared by way of macrocyclizations of
linear N-substituted oligoglycines. These compounds were used as molecular platforms to …

Toward 18F‐Labeled Theranostics: A Single Agent that Can Be Labeled with 18F, 64Cu, or 177Lu

ML Lepage, HT Kuo, Á Roxin, S Huh, Z Zhang… - …, 2020 - Wiley Online Library
We report a single‐molecule radiotracer that can be labeled independently with 18 F‐fluoride
or radiometals ( 64 Cu, 177 Lu) in a single step. A prostate‐specific membrane antigen (…