Recent studies have shown that intracellular Ca2+ handling is abnormal in the myocardium
of patients with end-stage heart failure. Muscles from the failing hearts showed a prolonged …

Cardiac PET using 18 F-FDG under fasting conditions (fasting 18 F-FDG PET) is a promising
technique for identification of cardiac sarcoidosis and assessment of disease activity. The …

Recent reports have demonstrated the presence of two isoforms of troponin I in the human
fetal heart, namely, cardiac troponin I and slow skeletal muscle troponin I. Structural and …

Doxorubicin (DOX)–induced cardiomyopathy has been found to be associated with impaired
Ca 2+ handling in the sarcoplasmic reticulum (SR), leading to reduced cardiac function. We …

We have recently identified a novel gene, termedklotho,that is involved in the suppression
of several aging phenotypes. The gene encodes a membrane protein that shares sequence …

Excessive fibrosis contributes to an increase in left ventricular stiffness. The goal of the
present study was to investigate the role of connective tissue growth factor (CCN2/CTGF), a …

Notch is an ancient cell-signaling system that regulates the specification of cell fate. This
study examined the role of Notch in the epithelial–mesenchymal transition (EMT) and …

The purpose of this study was to determine the expression of genes encoding various
sarcoplasmic reticulum components that are functionally coupled with calcium release, uptake, …

Background The aim of this study was to investigate whether left atrial (LA) strain has incremental
value over the CHA 2 DS 2 -VASc score for stratifying the risk for embolism in patients …

The Notch signaling pathway plays a crucial role in specifying cellular fates by interaction
between cellular neighbors; however, the molecular mechanism underlying smooth muscle …