A new gene, termed klotho, has been identified that is involved in the suppression of several
ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome …

Recent studies have established oxidative modification of low density lipoprotein (LDL) as
an important atherogenic factor. We examined the clinical relevance of circulating oxidized …

Recently cellular protooncogenes have been found to be induced as an early response to
pressure overload in cardiac hypertrophy. To examine whether mechanical stimuli directly …

We recently isolated a Krüppel-like zinc-finger transcription factor 5 (KLF5; also known as
BTEB2 and IKLF), which is markedly induced in activated vascular smooth-muscle cells and …

Arteriosclerosis caused by aging is recognized to be a crucial risk factor of cardiovascular
disease. We recently establishedklothomouse which causes age-related disorders including …

Cardiac PET using 18 F-FDG under fasting conditions (fasting 18 F-FDG PET) is a promising
technique for identification of cardiac sarcoidosis and assessment of disease activity. The …

To examine the molecular mechanisms by which mechanical stimuli induce cardiac
hypertrophy and specific gene expression, we cultured rat neonatal cardiocytes in deformable …

The klotho gene, originally identified by insertional mutagenesis in mice, suppresses multiple
aging phenotypes (eg, arteriosclerosis, pulmonary emphysema, osteoporosis, infertility, …

Background Cardiotoxicity leading to congestive heart failure is a complication of the
anthracyclines. Biochemical methods to diagnose and monitor cardiac function after anthracycline …

Doxorubicin (DOX)–induced cardiomyopathy has been found to be associated with impaired
Ca 2+ handling in the sarcoplasmic reticulum (SR), leading to reduced cardiac function. We …