Background Exome sequencing in hundreds of thousands of persons may enable the
identification of rare protein-coding genetic variants associated with protection from human …

Respiratory motion during positron emission tomography (PET)/computed tomography (CT)
imaging can cause significant image blurring and underestimation of tracer concentration for …

Background We quantified myocardial blood flow with 82 Rb PET using parameters of the
generalized Renkin-Crone model estimated from 82 Rb and 15 O-water images reconstructed …

Body fat distribution is a major, heritable risk factor for cardiometabolic disease, independent
of overall adiposity. Using exome-sequencing in 618,375 individuals (including 160,058 …

Parametric images for dynamic positron emission tomography (PET) are typically generated
by an indirect method, ie reconstructing a time series of emission images, then fitting a …

Existing respiratory motion-correction methods are applied only to static PET imaging. We
have previously developed an event-by-event respiratory motion-correction method with …

Liver zonation characterizes the separation of metabolic pathways along the lobules and is
required for optimal hepatic function. Wnt signaling is a master regulator of spatial liver …

Purpose Cardiac perfusion PET data can be reconstructed as a dynamic sequence and
kinetic modeling performed to quantify myocardial blood flow, or reconstructed as static gated …

Positron emission tomography (PET) imaging with the glucose analog 2-deoxy-2-[18 F]
fluoro-D-glucose ([18 F] FDG) has demonstrated clinical utility for the monitoring of brain glucose …

The aim of this research is to extend a direct parametric reconstruction algorithm for dynamic
PET to include spillover terms for use in cardiac perfusion imaging. Perfusion imaging with …