Serial microPET measures of the metabolic reaction to a microdialysis probe implant

WK Schiffer, MM Mirrione, A Biegon, DL Alexoff… - Journal of neuroscience …, 2006 - Elsevier
Despite the widespread use of chronic brain implants in experimental and clinical settings,
the effects of these long-term procedures on brain metabolism and receptor expression …

A novel approach for imaging brain–behavior relationships in mice reveals unexpected metabolic patterns during seizures in the absence of tissue plasminogen …

MM Mirrione, WK Schiffer, JS Fowler, DL Alexoff… - Neuroimage, 2007 - Elsevier
Medically refractory seizures cause inflammation and neurodegeneration. Seizure initiation
thresholds have been linked in mice to the serine protease tissue plasminogen activator (tPA…

Optimizing experimental protocols for quantitative behavioral imaging with 18F-FDG in rodents

WK Schiffer, MM Mirrione… - Journal of Nuclear …, 2007 - Soc Nuclear Med
Small-animal PET provides the opportunity to image brain activation during behavioral tasks
in animal models of human conditions. The present studies aimed to simplify behavioral …

[HTML][HTML] Increased metabolic activity in the septum and habenula during stress is linked to subsequent expression of learned helplessness behavior

MM Mirrione, D Schulz, KAB Lapidus… - Frontiers in human …, 2014 - frontiersin.org
Uncontrollable stress can have a profound effect on an organism's ability to respond
effectively to future stressful situations. Behavior subsequent to uncontrollable stress can vary …

Microglial ablation and lipopolysaccharide preconditioning affects pilocarpine-induced seizures in mice

MM Mirrione, DK Konomos, I Gravanis, SL Dewey… - Neurobiology of …, 2010 - Elsevier
Activated microglia have been associated with neurodegeneration in patients and in animal
models of Temporal Lobe Epilepsy (TLE), however their precise functions as neurotoxic or …

[HTML][HTML] Whole-brain mapping of neuronal activity in the learned helplessness model of depression

Y Kim, Z Perova, MM Mirrione, K Pradhan… - Frontiers in neural …, 2016 - frontiersin.org
Some individuals are resilient, whereas others succumb to despair in repeated stressful
situations. The neurobiological mechanisms underlying such divergent behavioral responses …

PET imaging of glucose metabolism in a mouse model of temporal lobe epilepsy

MM Mirrione, WK Schiffer, M Siddiq, SL Dewey… - Synapse, 2006 - Wiley Online Library
Here we present the first demonstration that 2‐deoxy‐2[ 18 F]fluoro‐D‐glucose ( 18 FDG) and
micro Positron Emission Tomography (μPET) can be used successfully to monitor regional …

Cognitive aspects of congenital learned helplessness and its reversal by the monoamine oxidase (MAO)-B inhibitor deprenyl

D Schulz, MM Mirrione, FA Henn - Neurobiology of learning and memory, 2010 - Elsevier
Cognitive processes are assumed to change with learned helplessness, an animal model of
depression, but little is known about such deficits. Here we investigated the role of cognitive …

Emerging, reemerging, and forgotten brain areas of the reward circuit: Notes from the 2010 Motivational Neural Networks conference

…, EC Dumont, SM Graves, MM Mirrione… - Behavioural brain …, 2011 - Elsevier
… plenary lectures by two distinguished guests: Gary Aston-Jones presented recent findings
from his group on the role of orexin neurons in drug and natural reward seeking, and Martine

Tissue plasminogen activator alters intracellular sequestration of zinc through interaction with the transporter ZIP4

J Emmetsberger, MM Mirrione, C Zhou… - Journal of …, 2010 - Soc Neuroscience
Glutamatergic neurons contain free zinc packaged into neurotransmitter-loaded synaptic
vesicles. Upon neuronal activation, the vesicular contents are released into the synaptic space, …