To clarify the role of microglia in brain homeostasis and disease, an understanding of their
maintenance, proliferation and turnover is essential. The lifespan of brain microglia, however, …

10.7554/eLife.14315.001 Identification of the cellular players and molecular messengers
that communicate neuronal activity to the vasculature driving cerebral hemodynamics is …

Human cortical organoids, three-dimensional neuronal cultures, are emerging as powerful
tools to study brain development and dysfunction. However, whether organoids can …

Recent advances in optical technologies such as multi-photon microscopy and optogenetics
have revolutionized our ability to record and manipulate neuronal activity. Combining …

Meiosis in mammalian oocytes is paused until luteinizing hormone (LH) activates receptors
in the mural granulosa cells of the ovarian follicle. Prior work has established the central role …

To explore the functional significance of cGMP-dependent protein kinase type I (cGKI) in the
regulation of erythrocyte survival, gene-targeted mice lacking cGKI were compared with …

Background Functional magnetic resonance imaging (fMRI) in awake behaving mice is well
positioned to bridge the detailed cellular-level view of brain activity, which has become …

The enhanced electrochemical activity of nanostructured materials is readily exploited in
energy devices, but their utility in scalable and human-compatible implantable neural interfaces …

The Utah array powers cutting‐edge projects for restoration of neurological function, such as
BrainGate, but the underlying electrode technology has itself advanced little in the last three …

Rationale: Cyclic GMP (cGMP) is an important intracellular signaling molecule in the
cardiovascular system, but its spatiotemporal dynamics in vivo is largely unknown. Objective: To …