The typical functional magnetic resonance (fMRI) study presents a formidable problem of
multiple statistical comparisons (ie, > 10,000 in a 128 x 128 image). To protect against false …

Importance There are limited efficacious treatments for Alzheimer disease. Objective To assess
efficacy and adverse events of donanemab, an antibody designed to clear brain amyloid …

Alzheimer's disease (AD) and antecedent factors associated with AD were explored using
amyloid imaging and unbiased measures of longitudinal atrophy in combination with …

The use of positron emission tomography to measure regional changes in average blood
flow during processing of individual auditory and visual words provides support for multiple, …

… An important corollary of Mintun's formulation is that binding potential equals a particular
volume of distribution, namely, that of the specific (receptor bound) radioligand. The equivalence …

Objectives Amyloid‐β 42 (Aβ 42 ) appears central to Alzheimer's disease (AD) pathogenesis
and is a major component of amyloid plaques. Mean cerebrospinal fluid (CSF) Aβ 42 is …

Brain glucose uptake, oxygen metabolism, and blood flow in humans were measured with
positron emission tomography, and a resting-state molar ratio of oxygen to glucose …

Importance Cerebral amyloid-β aggregation is an early pathological event in Alzheimer
disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid …

Functional brain imaging with positron emission tomography and magnetic resonance imaging
has been used extensively to map regional changes in brain activity. The signal used by …

This study takes advantage of continuing advances in the precision of magnetic resonance
imaging (MRI) to quantify hippocampal volumes in a series of human subjects with a history …