[PDF][PDF] Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models
Hematopoietic stem cells (HSCs) are used in transplantation therapy to reconstitute the
hematopoietic system. Human cord blood (hCB) transplantation has emerged as an attractive …
hematopoietic system. Human cord blood (hCB) transplantation has emerged as an attractive …
[HTML][HTML] Pharmacological modulation of humoral immunity in a nonhuman primate model of AAV gene transfer for hemophilia B
…, SC Edmonson, A Tai, SD Price, ME Metzger… - Molecular Therapy, 2012 - cell.com
Liver gene transfer for hemophilia B has shown very promising results in recent clinical
studies. A potential complication of gene-based treatments for hemophilia and other inherited …
studies. A potential complication of gene-based treatments for hemophilia and other inherited …
[PDF][PDF] Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study
In mice, clonal tracking of hematopoietic stem cells (HSCs) has revealed variations in
repopulation characteristics. However, it is unclear whether similar properties apply in primates. …
repopulation characteristics. However, it is unclear whether similar properties apply in primates. …
Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus–based lentiviral vector system
H Hanawa, P Hematti, K Keyvanfar, ME Metzger… - Blood, 2004 - ashpublications.org
High-titer, HIV-1–based lentiviral vector particles were found to transduce cytokine-mobilized
rhesus macaque CD34 + cells and clonogenic progenitors very poorly (< 1%), reflecting …
rhesus macaque CD34 + cells and clonogenic progenitors very poorly (< 1%), reflecting …
Toxicity of a first-generation adenoviral vector in rhesus macaques
…, TH Mondoro, DM Krizek, ME Metzger… - Human gene …, 2002 - liebertpub.com
We constructed a first-generation adenovirus vector (AVC3FIX5) that we used to assess the
rhesus macaque as a nonhuman primate model for preclinical testing of hemophilia B gene …
rhesus macaque as a nonhuman primate model for preclinical testing of hemophilia B gene …
[HTML][HTML] Path to the clinic: assessment of iPSC-based cell therapies in vivo in a nonhuman primate model
…, S Pittaluga, A Nicolae, RE Donahue, ME Metzger… - Cell reports, 2014 - cell.com
Induced pluripotent stem cell (iPSC)-based cell therapies have great potential for regenerative
medicine but are also potentially associated with tumorigenic risks. Current rodent …
medicine but are also potentially associated with tumorigenic risks. Current rodent …
Plerixafor (AMD3100) and granulocyte colony-stimulating factor (G-CSF) mobilize different CD34+ cell populations based on global gene and microRNA expression …
…, ME Metzger, J Ren, E Wang… - Blood, The Journal …, 2009 - ashpublications.org
Plerixafor (AMD3100) and granulocyte colony-stimulating factor (G-CSF) mobilize peripheral
blood stem cells by different mechanisms. A rhesus macaque model was used to compare …
blood stem cells by different mechanisms. A rhesus macaque model was used to compare …
Significant mobilization of both conventional and regulatory T cells with AMD3100
…, AC Bonifacino, ME Metzger… - Blood, The Journal …, 2011 - ashpublications.org
In this study, we used the rhesus macaque model to determine the impact that AMD3100
has on lymphocyte mobilization, both alone and in combination with G-CSF. Our results …
has on lymphocyte mobilization, both alone and in combination with G-CSF. Our results …
Adenovirus-Mediated Expression of Human Coagulation Factor IX in the Rhesus Macaque Is Associated With Dose-Limiting Toxicity: Presented in part at the 40th …
JN Lozier, ME Metzger, RE Donahue… - Blood, The Journal of …, 1999 - ashpublications.org
We used a first-generation adenovirus vector (AVC3FIX5) to assess whether human factor
IX could be expressed and detected in the rhesus macaque, which we have shown does not …
IX could be expressed and detected in the rhesus macaque, which we have shown does not …
Development of a human immunodeficiency virus type 1-based lentiviral vector that allows efficient transduction of both human and rhesus blood cells
…, AC Bonifacino, AE Krouse, ME Metzger… - Journal of …, 2009 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1) vectors transduce rhesus blood cells poorly
due to a species-specific block by TRIM5α and APOBEC3G, which target HIV-1 capsid and …
due to a species-specific block by TRIM5α and APOBEC3G, which target HIV-1 capsid and …