User profiles for Mark Aplin

Mark Aplin

Verified email at dadlnet.dk
Cited by 934

S100A4 is upregulated in injured myocardium and promotes growth and survival of cardiac myocytes

M Schneider, S Kostin, CC Strøm, M Aplin… - Cardiovascular …, 2007 - academic.oup.com
Objective The multifunctional Ca 2+ -binding protein S100A4 (also known as Mts1 and Fsp1)
is involved in fibrosis and tissue remodeling in several diseases including cancer, kidney …

Expression profiling reveals differences in metabolic gene expression between exercise‐induced cardiac effects and maladaptive cardiac hypertrophy

CC Strøm, M Aplin, T Ploug… - The FEBS …, 2005 - Wiley Online Library
While cardiac hypertrophy elicited by pathological stimuli eventually leads to cardiac
dysfunction, exercise‐induced hypertrophy does not. This suggests that a beneficial hypertrophic …

Prognostic importance of complete atrioventricular block complicating acute myocardial infarction

M Aplin, T Engstrøm, NG Vejlstrup… - The American journal of …, 2003 - Elsevier
Third-degree atrioventricular block after acute myocardial infarction is considered to have
prognostic importance. However, its importance in conjunction with thrombolytic therapy and …

Differential extracellular signal‐regulated kinases 1 and 2 activation by the angiotensin type 1 receptor supports distinct phenotypes of cardiac myocytes

M Aplin, GL Christensen, M Schneider… - Basic & clinical …, 2007 - Wiley Online Library
The angiotensin II (AngII) type 1 receptor (AT 1 R) is a seven‐transmembrane receptor well
established to activate extracellular signal‐regulated kinases 1 and 2 (ERK1/2) by discrete G …

The angiotensin type 1 receptor activates extracellular signal‐regulated kinases 1 and 2 by G protein‐dependent and‐independent pathways in cardiac myocytes and …

M Aplin, GL Christensen, M Schneider… - Basic & clinical …, 2007 - Wiley Online Library
The angiotensin II (AngII) type 1 receptor (AT 1 R) has been shown to activate extracellular
signal‐regulated kinases 1 and 2 (ERK1/2) through G proteins or G protein‐independently …

Molecular determinants of angiotensin II type 1 receptor functional selectivity

M Aplin, MM Bonde, JL Hansen - Journal of molecular and cellular …, 2009 - Elsevier
The angiotensin AT 1 receptor is an important pharmacological target in the treatment of
cardiovascular disorders, such as hypertension, diabetic nephropathy, cardiac hypertrophy, …

Cardiac remodelling and function with primary mitral valve insufficiency studied by magnetic resonance imaging

M Aplin, K Kyhl, J Bjerre, N Ihlemann… - European Heart …, 2016 - academic.oup.com
Aims Evaluation of patients with primary mitral valve insufficiency (MI) is best supported by
quantitative measures. Cardiovascular magnetic resonance imaging (CMR) offers flow and …

Quantitative [123] I-Ioflupane DaTSCAN single-photon computed tomography-computed tomography in Parkinsonism

…, P Begley, M Jessop, N Singh, M Aplin… - Nuclear Medicine …, 2023 - journals.lww.com
Aim [123] I-Ioflupane (DaTSCAN) binds to the presynaptic dopamine transporter (DAT) and
with a lower affinity to the serotonin transporter (SERT). We aimed to develop a novel method …

[HTML][HTML] Glucose homeostasis in mice is transglutaminase 2 independent

SE Iismaa, M Aplin, S Holman, TW Yiu, K Jackson… - PLoS …, 2013 - journals.plos.org
Transglutaminase type 2 (TG2) has been reported to be a candidate gene for maturity onset
diabetes of the young (MODY) because three different mutations that impair TG2 …

Pharmacologic perspectives of functional selectivity by the angiotensin II type 1 receptor

M Aplin, GL Christensen, JL Hansen - Trends in cardiovascular medicine, 2008 - Elsevier
The angiotensin II type 1 (AT 1 ) receptor plays a key role in cardiovascular pathophysiology,
and it is a major pharmacologic target in the treatment of many cardiovascular disorders. …