User profiles for Mark Aplin
Mark AplinVerified email at dadlnet.dk Cited by 934 |
S100A4 is upregulated in injured myocardium and promotes growth and survival of cardiac myocytes
M Schneider, S Kostin, CC Strøm, M Aplin… - Cardiovascular …, 2007 - academic.oup.com
Objective The multifunctional Ca 2+ -binding protein S100A4 (also known as Mts1 and Fsp1)
is involved in fibrosis and tissue remodeling in several diseases including cancer, kidney …
is involved in fibrosis and tissue remodeling in several diseases including cancer, kidney …
Expression profiling reveals differences in metabolic gene expression between exercise‐induced cardiac effects and maladaptive cardiac hypertrophy
CC Strøm, M Aplin, T Ploug… - The FEBS …, 2005 - Wiley Online Library
While cardiac hypertrophy elicited by pathological stimuli eventually leads to cardiac
dysfunction, exercise‐induced hypertrophy does not. This suggests that a beneficial hypertrophic …
dysfunction, exercise‐induced hypertrophy does not. This suggests that a beneficial hypertrophic …
Prognostic importance of complete atrioventricular block complicating acute myocardial infarction
M Aplin, T Engstrøm, NG Vejlstrup… - The American journal of …, 2003 - Elsevier
Third-degree atrioventricular block after acute myocardial infarction is considered to have
prognostic importance. However, its importance in conjunction with thrombolytic therapy and …
prognostic importance. However, its importance in conjunction with thrombolytic therapy and …
Differential extracellular signal‐regulated kinases 1 and 2 activation by the angiotensin type 1 receptor supports distinct phenotypes of cardiac myocytes
M Aplin, GL Christensen, M Schneider… - Basic & clinical …, 2007 - Wiley Online Library
The angiotensin II (AngII) type 1 receptor (AT 1 R) is a seven‐transmembrane receptor well
established to activate extracellular signal‐regulated kinases 1 and 2 (ERK1/2) by discrete G …
established to activate extracellular signal‐regulated kinases 1 and 2 (ERK1/2) by discrete G …
The angiotensin type 1 receptor activates extracellular signal‐regulated kinases 1 and 2 by G protein‐dependent and‐independent pathways in cardiac myocytes and …
M Aplin, GL Christensen, M Schneider… - Basic & clinical …, 2007 - Wiley Online Library
The angiotensin II (AngII) type 1 receptor (AT 1 R) has been shown to activate extracellular
signal‐regulated kinases 1 and 2 (ERK1/2) through G proteins or G protein‐independently …
signal‐regulated kinases 1 and 2 (ERK1/2) through G proteins or G protein‐independently …
Molecular determinants of angiotensin II type 1 receptor functional selectivity
M Aplin, MM Bonde, JL Hansen - Journal of molecular and cellular …, 2009 - Elsevier
The angiotensin AT 1 receptor is an important pharmacological target in the treatment of
cardiovascular disorders, such as hypertension, diabetic nephropathy, cardiac hypertrophy, …
cardiovascular disorders, such as hypertension, diabetic nephropathy, cardiac hypertrophy, …
Cardiac remodelling and function with primary mitral valve insufficiency studied by magnetic resonance imaging
Aims Evaluation of patients with primary mitral valve insufficiency (MI) is best supported by
quantitative measures. Cardiovascular magnetic resonance imaging (CMR) offers flow and …
quantitative measures. Cardiovascular magnetic resonance imaging (CMR) offers flow and …
Quantitative [123] I-Ioflupane DaTSCAN single-photon computed tomography-computed tomography in Parkinsonism
…, P Begley, M Jessop, N Singh, M Aplin… - Nuclear Medicine …, 2023 - journals.lww.com
Aim [123] I-Ioflupane (DaTSCAN) binds to the presynaptic dopamine transporter (DAT) and
with a lower affinity to the serotonin transporter (SERT). We aimed to develop a novel method …
with a lower affinity to the serotonin transporter (SERT). We aimed to develop a novel method …
[HTML][HTML] Glucose homeostasis in mice is transglutaminase 2 independent
Transglutaminase type 2 (TG2) has been reported to be a candidate gene for maturity onset
diabetes of the young (MODY) because three different mutations that impair TG2 …
diabetes of the young (MODY) because three different mutations that impair TG2 …
Pharmacologic perspectives of functional selectivity by the angiotensin II type 1 receptor
M Aplin, GL Christensen, JL Hansen - Trends in cardiovascular medicine, 2008 - Elsevier
The angiotensin II type 1 (AT 1 ) receptor plays a key role in cardiovascular pathophysiology,
and it is a major pharmacologic target in the treatment of many cardiovascular disorders. …
and it is a major pharmacologic target in the treatment of many cardiovascular disorders. …