Aldehyde dehydrogenases (ALDHs) are promising cancer drug targets, as certain isoforms
are required for the survival of stem-like tumor cells. We have discovered selective inhibitors …

Rationale: First-line therapy for high-grade gliomas (HGGs) includes maximal safe surgical
resection. The extent of resection predicts overall survival, but current neuroimaging …

There has been continual development of fluorescent agents, imaging systems, and their
applications over the past several decades. With the recent FDA approvals of 5-aminolevulinic …

Purpose: Fluorescence molecular imaging, using cancer-targeted near infrared (NIR)
fluorescent probes, offers the promise of accurate tumor delineation during surgeries and the …

Objective Fluorescence‐guided surgery (FGS) is a rapidly developing intraoperative
technology, and many contrast agents are currently under investigation. We sought to provide a …

Purpose: Determine the safety and specificity of a tumor-targeted radiotracer ( 89 Zr-pan) in
combination with 18 F-FDG PET/CT to improve diagnostic accuracy in head and neck …

Clinical imaging performance using a fluorescent antibody was compared across 3 cancers
to elucidate physical and biologic factors contributing to differential translation of epidermal …

Epidermal growth factor receptor (EGFR) is highly expressed in 80-90% of head and neck
squamous cell carcinomas (HNSCCs), making it an ideal target for antibody-drug conjugates (…

Gli transcription factors within the Hedgehog (Hh) signaling pathway direct key events in
mammalian development and promote a number of human cancers. Current therapies for Gli‐…

Purpose: Conjunctival squamous cell carcinoma (SCC) is a sight-threatening ocular surface
malignancy with the primary treatment modality being surgical resection. To evaluate …