Two diphosphonates containing the PCP bond, Cl 2 C(PO 3 HNa) 2 and H 2 C(PO 3 HNa) 2
retard the rate of dissolution of apatite crystals in vitro. They inhibit bone resorption induced …

Two diphosphonates containing the PCP bond, CH 3 C(OH)(PO 3 HNa) 2 and H 2 C(PO 3
HNa) 2 , inhibit the crystallization of calcium phosphate in vitro and prevent aortic calcification …

The formation of crystalline calcium hydroxyapatite from solutions of calcium and phosphate
ions and the inhibition of calcium hydroxyapatite crystal growth by polyphosphonates and …

Hydrated calcium monohydrogen phosphate is proposed as the logical precursor in the
formation of hydroxyapatite and a unifying theory for the formation of low calcium, or defect …

MATERIALSANDMETHODS A group of 1,891 patients from 16 medical insti tutions was
scanned during the clinical trials of the OOmTcSn. EHDP skeletal-imaging agent, Osteoscan®. …

One of the major successes of nuclear medicine in recent years has been the clinical utility
of the 99m Tc-Tabeled bone-imaging agents. This article is concerned with the evidence …

This study was performed to elucidate the localization at the cellular level of technetium-99m
phosphorus ( 99m Tc-P) radiopharmaceuticals in acute myocardial infarcts and the …

We have investigated the in vitro adsorption of three C-14-labeled diphosphonates on
calcium phosphate. The three are 1-hydroxy [1-14C] ethylidene diphosphonate (C-14 HEDP),[14C…

The retention of radioactivity in human, rat, and dog following a single injected dose of
radiolabeled etidronate disodium (EHDP) is shown to follow power‐law decay curves with similar …

Technetium-99m hydroxymethylene diphosphonate (Tc-99M HMDP) is a new diphosphonate
skeletal imaging agent. Animal studies show that Tc-99m HMDP has a higher uptake on …