Multiple D1 dopaminergic receptor subtypes have been postulated on the basis of pharmacological,
biochemical, and genetic studies. We describe the isolation and characterization of …

An aromatic residue, tyrosine 326 in the prototypical human beta 2-adrenergic receptor,
exists in a highly conserved sequence motif in virtually all members of the G protein-coupled …

Dopamine D1A and D1B receptor subtypes belong to the superfamily of G protein-coupled
receptors. Both receptors are coupled to the activation of adenylyl cyclase and exhibit distinct …

Dopamine D 5 receptor localization has been difficult because even the most specific
ligands cannot distinguish between molecular subtypes of the D 1 ‐like receptor subfamily. …

The role of G protein-coupled receptor kinases (GRKs) in the regulation of dopamine D1A
receptor responsiveness is poorly understood. To explore the potential role played by the …

The prevalence, presentation, and progression of Alzheimer’s disease (AD) differ between
men and women, although β-amyloid (Aβ) deposition is a pathological hallmark of AD in both …

Naïve sea bass juveniles (38.4 ± 4.5 g) were intramuscularly infected with a sublethal dose
of betanodavirus isolate 378/I03, followed after 43 days by a similar boosting. This infection …

β-Adrenergic receptors (βARs) are crucial for maintaining the rate and force of cardiac muscle
contraction in vertebrates. Zebrafish (Danio rerio) have one β1AR gene and two β2AR …

Studies of the serotonin (5-HT) receptors have illustrated several important concepts in G-protein-mediated
signaling. These concepts include G-protein specificity and cellular …

The concept of activation in the absence of agonists has been demonstrated for many GPCRs
and is now solidified as one of the principal aspects of GPCR signaling. In this chapter, we …