Previous in vitro studies have shown that isolated mitochondria can generate oxygen radicals.
However, whether a similar phenomenon can also occur in intact organs is unknown. In …

Several experimental and clinical studies have shown that oxidized low-density lipoprotein
and oxidation-sensitive mechanisms are central in the pathogenesis of vascular dysfunction …

Background. Studies in animals have shown that serotonin constricts coronary arteries if the
endothelium is damaged, but in vitro studies have revealed a vasodilating effect on isolated …

To test whether generation of oxygen radicals during postischemic reperfusion might
promote peroxidation of cardiac membrane lipids, four groups of Langendorff-perfused rabbit …

Background and Purpose— Atherosclerosis occurs later and is less extensive in intracranial
arteries than in extracranial arteries. However, the mechanisms responsible are poorly …

IMPLICATIONS: Massive oxidative injury may promote poor clinical outcome in critically ill
patients. This study demonstrates that antioxidant intervention is associated with reduced …

Tissue factor is a transmembrane protein that activates the extrinsic coagulation pathway by
binding factor VII. Endothelial cells, being in contact with circulating blood, do not normally …

Maternal hypercholesterolemia during pregnancy is associated with enhanced fatty streak
formation in human fetuses and faster progression of atherosclerosis during childhood even …

Plasma levels of erythropoietin (mU/ml) were measured in patients with congestive heart
failure (CHF) (n = 108) and in a control group of normal subjects (n = 45). In normal subjects, …

BACKGROUND Heart period variability provides useful prognostic information on autonomic
cardiac control, and a strong association has been demonstrated after myocardial infarction …