[HTML][HTML] Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma
M Castro, J Corren, ID Pavord, J Maspero… - New England journal …, 2018 - Mass Medical Soc
Background Dupilumab is a fully human anti–interleukin-4 receptor α monoclonal antibody
that blocks both interleukin-4 and interleukin-13 signaling. We assessed its efficacy and …
that blocks both interleukin-4 and interleukin-13 signaling. We assessed its efficacy and …
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Severe or therapy-resistant asthma is increasingly recognised as a major unmet need. A
Task Force, supported by the European Respiratory Society and American Thoracic Society, …
Task Force, supported by the European Respiratory Society and American Thoracic Society, …
Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo …
M Castro, J Zangrilli, ME Wechsler… - The Lancet …, 2015 - thelancet.com
Background Elevated numbers of blood eosinophils are a risk factor for asthma exacerbations.
Reslizumab is a humanised anti-interleukin 5 monoclonal antibody that disrupts …
Reslizumab is a humanised anti-interleukin 5 monoclonal antibody that disrupts …
Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial
M Castro, AS Rubin, M Laviolette… - American journal of …, 2010 - atsjournals.org
Rationale: Bronchial thermoplasty (BT) is a bronchoscopic procedure in which controlled
thermal energy is applied to the airway wall to decrease smooth muscle. Objectives: To …
thermal energy is applied to the airway wall to decrease smooth muscle. Objectives: To …
Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study
M Castro, S Mathur, F Hargreave, LP Boulet… - American journal of …, 2011 - atsjournals.org
Rationale: Eosinophilic asthma is a phenotype of asthma characterized by the persistence
of eosinophils in the airways. IL-5 is involved in the activation and survival of eosinophils. …
of eosinophils in the airways. IL-5 is involved in the activation and survival of eosinophils. …
Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program
…, H Li, X Li, R D'Agostino Jr, M Castro… - American journal of …, 2010 - atsjournals.org
Rationale: The Severe Asthma Research Program cohort includes subjects with persistent
asthma who have undergone detailed phenotypic characterization. Previous univariate …
asthma who have undergone detailed phenotypic characterization. Previous univariate …
Characterization of the severe asthma phenotype by the national heart, lung, and blood institute's severe asthma research program
…, L Bacharier, WJ Calhoun, M Castro… - Journal of Allergy and …, 2007 - Elsevier
BACKGROUND: Severe asthma causes the majority of asthma morbidity. Understanding
mechanisms that contribute to the development of severe disease is important. OBJECTIVE: …
mechanisms that contribute to the development of severe disease is important. OBJECTIVE: …
[HTML][HTML] Efficacy and safety of dupilumab in glucocorticoid-dependent severe asthma
…, G Brusselle, JF Maspero, M Castro… - New England journal …, 2018 - Mass Medical Soc
Background Dupilumab is a fully human anti–interleukin-4 receptor α monoclonal antibody
that blocks both interleukin-4 and interleukin-13 signaling. Its effectiveness in reducing oral …
that blocks both interleukin-4 and interleukin-13 signaling. Its effectiveness in reducing oral …
Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist …
S Wenzel, M Castro, J Corren, J Maspero, L Wang… - The Lancet, 2016 - thelancet.com
Background Dupilumab, a fully human anti-interleukin-4 receptor α monoclonal antibody,
inhibits interleukin-4 and interleukin-13 signalling, key drivers of type-2-mediated inflammation…
inhibits interleukin-4 and interleukin-13 signalling, key drivers of type-2-mediated inflammation…
[HTML][HTML] Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations
…, KF Chung, H Vora, X Li, WJ Calhoun, M Castro… - Nature …, 2011 - ncbi.nlm.nih.gov
Asthma is a common disease with a complex risk architecture including both genetic and
environmental factors. We performed a meta-analysis of North American genome-wide …
environmental factors. We performed a meta-analysis of North American genome-wide …