Lentiviral delivery of glial cell line–derived neurotrophic factor (lenti-GDNF) was tested for
its trophic effects upon degenerating nigrostriatal neurons in nonhuman primate models of …

The move from reading to writing the human genome offers new opportunities to improve
human health. The United States National Institutes of Health (NIH) Somatic Cell Genome …

Although the role of dopamine dysfunction is well established in Parkinson's disease, the
effect of nigrostriatal degeneration on motor performance during normal aging is less well …

By sequentially applying sonic hedgehog (C25II) and CHIR99021 (GSK3β inhibitor) to induce
the midbrain floor plate (FP) progenitors and fibroblast growth factor 8 (FGF8) to promote …

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the
progressive loss of dopaminergic nigral neurons and striatal dopamine. Despite the advances …

Non-human primates have a small but important role in basic and translational biomedical
research, owing to similarities with human beings in physiology, cognitive capabilities, …

Background Activation of the peroxisome proliferator-activated receptor gamma (PPAR-γ)
has been proposed as a possible neuroprotective strategy to slow down the progression of …

The primate striatum contains tyrosine hydroxylase (TH)-immunoreactive (ir) neurons, the
numbers of which are augmented after dopamine depletion. Glial cell line-derived …

Nonhuman primate (NHP) models of Parkinson's disease (PD) play an essential role in the
understanding of PD pathophysiology and the assessment of PD therapies. NHP research …

The generation of induced pluripotent stem cells (iPSCs) opens up the possibility for
personalized cell therapy. Here, we show that transplanted autologous rhesus monkey iPSC-…