The display of repertoires of human antibody (Ab) fragments on filamentous phages and
selection by binding of the phage to antigen (Ag) have provided a ready means of deriving …

Promising targeted treatments and immunotherapy strategies in oncology and advancements
in our understanding of molecular pathways that underpin cancer development have …

The costimulatory effects of CD27 on T lymphocyte effector function and memory formation
has been confined to evaluations in mouse models, in vitro human cell culture systems, and …

Human T cells engineered to express a chimeric antigen receptor (CAR) specific for folate
receptor-α (FRα) have shown robust antitumor activity against epithelial cancers in vitro but …

Background The poor prognosis and the limited efficacy of targeted therapy in patients with
triple-negative breast cancer (TNBC) have raised the need for alternative therapies. Recent …

Purpose: Prostate cancer remains the second most frequent cause of tumor-related deaths in
the Western world. Additional markers for the identification of prostate cancer development …

Folate receptors and transporters and one-carbon metabolism continue to be important
areas of study given their essential roles in an assortment of diseases and as targets for …

Novel Ab-based immunotherapeutic strategies have exploited T-cell receptor-like chimeric
immune receptors (CIR) expressed on the surface of transduced human peripheral blood …

Background Survival rates for ovarian cancer remain poor, and monitoring and prediction of
therapeutic response may benefit from additional markers. Ovarian cancers frequently …

Chimeric antigen receptors (CARs) can redirect T cells against antigen-expressing tumors in
an HLA-independent manner. To date, various CARs have been constructed using mouse …